FGFR3
fibroblast growth factor receptor 3
Sinonimi:
ACH, CD333, CEK2, HSFGFR3EX, JTK4
Specie:
Human FGFR3 (2261), Mouse Fgfr3 (14184), Rat Fgfr3 (84489), Zebrafish fgfr3 (58129), chicken FGFR3 (396515), cow FGFR3 (281769), Horse FGFR3 (100034114), domestic cat FGFR3 (100141386), dog FGFR3 (488808), sheep FGFR3 (554324) ...Più
ID UniProtKB:
ID gene:
- Human(2261) Summary: This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009]
- Mouse(14184) fibroblast growth factor receptor 3
- Rat(84489) fibroblast growth factor receptor 3
- Zebrafish(58129) fibroblast growth factor receptor 3
- chicken(396515) fibroblast growth factor receptor 3
- cow(281769) fibroblast growth factor receptor 3
- Horse(100034114) fibroblast growth factor receptor 3
- domestic cat(100141386) fibroblast growth factor receptor 3
- dog(488808) fibroblast growth factor receptor 3
- sheep(554324) fibroblast growth factor receptor 3
- naked mole-rat(101711651) fibroblast growth factor receptor 3
- domestic guinea pig(100732948) fibroblast growth factor receptor 3
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Antibodies
N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-Fibroblast Growth Factor Receptor-3, Cytoplasmic antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Reattività con
human
Applicazione
immunohistochemistry
western blot
western blot
Anti-Fibroblast Growth Factor Receptor-3, Extracellular antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Reattività con
human
Applicazione
immunohistochemistry
western blot
western blot
Anti-FGFR3 antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-FGFR3 antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Small Molecule - Inhibitor
N° Catalogo
Descrizione
Specie
Proteins
N° Catalogo
Descrizione
Specie
FGFR3 (397-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Specie
human
FGFR3 (K650E), active, GST tagged human, PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Specie
human