- Crotylboron-based synthesis of the polypropionate units of chaxamycins A/D, salinisporamycin, and rifamycin S.
Crotylboron-based synthesis of the polypropionate units of chaxamycins A/D, salinisporamycin, and rifamycin S.
The Journal of organic chemistry (2012-06-19)
Ming Chen, William R Roush
PMID22703288
RÉSUMÉ
Syntheses of the C(15)-C(27) fragments of chaxamycins A/D, rifamycin S, and the C(12)-C(24) fragment of salinisporamycin have been accomplished in 10 steps from commercially available starting materials. Three crotylboron reagents were utilized to construct the seven contiguous stereocenters in these fragments with excellent stereoselectivity.
MATÉRIAUX
Référence du produit
Marque
Description du produit
Rifamycin S, European Pharmacopoeia (EP) Reference Standard