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V4640

Sigma-Aldrich

VU0357017 monohydrochloride

≥98% (HPLC)

Synonyme(s) :

4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride, CID 25010775, ML071 hydrochloride, SID 56353039

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About This Item

Formule empirique (notation de Hill):
C18H27N3O3 · HCl
Numéro CAS:
1135242-13-5
Poids moléculaire :
369.89
Numéro MDL:
MFCD17215959
Code UNSPSC :
12352200
ID de substance PubChem :
329829053
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white to off-white

Solubilité

DMSO: ≥10 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

Cl.CCOC(=O)N1CCC(CC1)NCCNC(=O)c2ccccc2C

InChI

1S/C18H27N3O3.ClH/c1-3-24-18(23)21-12-8-15(9-13-21)19-10-11-20-17(22)16-7-5-4-6-14(16)2;/h4-7,15,19H,3,8-13H2,1-2H3,(H,20,22);1H

Clé InChI

XKJQVUIXSBOCPP-UHFFFAOYSA-N

Actions biochimiques/physiologiques

VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by scopolamine in a preclinical rodent model.

Caractéristiques et avantages

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Andreia N Horácio et al.
PloS one, 8(9), e73704-e73704 (2013-09-26)
In Portugal, pneumococcal conjugate vaccines have been administered to children outside of the national immunization plan since 2001. We determined the serotype and antimicrobial susceptibility of 1265 isolates responsible for adult invasive pneumococcal infections (IPD) between 2009 and 2011 and
Masayuki Ikeno et al.
The International journal of oral & maxillofacial implants, 28(5), e283-e289 (2013-09-26)
The objective of this pilot study was to histologically evaluate bone regeneration using a self-assembling peptide hydrogel scaffold with recombinant human bone morphogenetic protein-2 (rhBMP-2) in a rabbit calvaria model. Five adult New Zealand White rabbits were used for the
Yong Min Kwon et al.
International journal of systematic and evolutionary microbiology, 64(Pt 2), 400-405 (2013-09-26)
A Gram-negative, proteorhodopsin-containing, orange pigmented, rod-shaped and strictly aerobic bacterium, designated strain AKS622(T), was isolated from a glacier core collected from the coast of King George Island, Antarctica. 16S rRNA gene sequence analysis revealed that strain AKS622(T) was affiliated to
Hsing-Yu Chen et al.
Evidence-based complementary and alternative medicine : eCAM, 2013, 125943-125943 (2013-09-26)
Asthma is one of the most common allergic respiratory diseases around the world and places great burden on medical payment. Chinese herbal medicine (CHM) is commonly used for Taiwanese children to control diseases. The aim of this study is to
Jamal Sarvari et al.
Hepatitis monthly, 13(7), e8351-e8351 (2013-09-26)
Hepatocellular carcinoma is a highly progressive cancer in the case of late diagnosis which is frequently associated with HBV and HCV viral infections. To identify differentially expressed serum proteins among three main stages of HCV infection and healthy individuals, and
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Articles

Acetylcholine Receptors (Muscarinic)

Muscarinic acetylcholine receptors are G protein-coupled receptors (GPCRs) and mediate acetylcholine actions in the CNS and non-nervous tissues. Learn more about acetylcholine receptors and their role in cell signaling.

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