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U4754

Sigma-Aldrich

Anti-Lectin, Ulex europaeus-I antibody produced in rabbit

whole antiserum, delipidized

Synonyme(s) :

Anti-Gorse or Furze Lectin, Anti-UEA-I

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About This Item

Numéro MDL:
MFCD00162898
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.46

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

whole antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

liquid

Contient

15 mM sodium azide

Espèces réactives

Ulex europaeus

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): suitable
indirect immunofluorescence: 1:500 using human tissue

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Description générale

The antibody may be used for studies of the vascular structures. It reacts specifically with UEA-I bound to human endothelial cells of normal and neoplastic blood and lymphatic vessels. Its uniform reaction with vessels enables differentation between vessels and artificial slits in the tissue.

Immunogène

Ulex europaeus from gorse seeds..

Application

Anti-Lectin, Ulex europaeus-I antibody produced in rabbit has been used in double immunostaining of muscle capillary sections.

Actions biochimiques/physiologiques

Lectin isolated from Ulex europaeus I is specific for α-L-fucose-containing glycocompounds. Due to this specificity it serves as a marker for vascular endothelial cells and tumors derived from them.

Description de la cible

Lectins are highly specific carbohydrate binding proteins useful in carbohydrate and cell membrane studies, as well as cell agglutination and typing techniques.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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H Holthöfer et al.
Laboratory investigation; a journal of technical methods and pathology, 47(1), 60-66 (1982-07-01)
Ulex europaeus I agglutinin, a lectin specific for some alpha-L-fucose-containing glycocompounds, was used in fluorescence microscopy to stain cryostat sections of human tissues. The endothelium of vessels of all sizes was stained ubiquitously in all tissues studied as judged by
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American journal of physiology. Gastrointestinal and liver physiology, 300(6), G1065-G1079 (2011-03-19)
Bone morphogenetic protein (BMP) signaling within the gastrointestinal tract is complex. BMP ligands and their receptors are expressed in both epithelial and mesenchymal compartments, suggesting bidirectional signaling between these two entities. Despite an increasing interest in BMP signaling in gut
M Miettinen et al.
American journal of clinical pathology, 79(1), 32-36 (1983-01-01)
Some skin and soft tumors, which generally are assumed to be derived from endothelial cells or blood vessels, were characterized with fluorochrome-labeled Ulex europaeus I agglutinin (UEA I), recently shown to bind specifically to endothelial cells in various normal human
J M Sweeter et al.
Scientific reports, 11(1), 13037-13037 (2021-06-24)
Exacerbations of muco-obstructive airway diseases such as COPD and asthma are associated with epithelial changes termed mucous metaplasia (MM). Many molecular pathways triggering MM have been identified; however, the factors that regulate resolution are less well understood. We hypothesized that
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