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T8703

Sigma-Aldrich

T0070907

≥98% (HPLC)

Synonyme(s) :

2-Chloro-5-nitro-N-4-pyridinyl-benzamide, Benzamide, 2-chloro-5-nitro-N-4-pyridinyl-

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About This Item

Formule empirique (notation de Hill):
C12H8ClN3O3
Numéro CAS:
313516-66-4
Poids moléculaire :
277.66
Numéro MDL:
MFCD00121849
Code UNSPSC :
12352203
ID de substance PubChem :
329826884
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white

Solubilité

DMSO: >10 mg/mL
H2O: insoluble

Température de stockage

2-8°C

Chaîne SMILES 

[O-][N+](=O)c1ccc(Cl)c(c1)C(=O)Nc2ccncc2

InChI

1S/C12H8ClN3O3/c13-11-2-1-9(16(18)19)7-10(11)12(17)15-8-3-5-14-6-4-8/h1-7H,(H,14,15,17)

Clé InChI

FRPJSHKMZHWJBE-UHFFFAOYSA-N

Description générale

T0070907 has antimicrotubule, antitumor and radiosensitizing properties. It decreases tubulin protein levels, which is associated with cell cycle arrest, apoptosis and also reduces metastasis of colorectal carcinoma cells. T0070907 is used as a therapeutic target in breast cancer. It stimulates proteasome-dependent degradation of tubulin.

Application

T0070907 has been used to reduce peroxisome proliferator-activated receptor gamma (PPAR-γ) expression in lipopolysaccharide (LPS)-induced leukemia RAW264.7 cell line. It also has been used to evaluate the involvement of wogonin in alleviating EtOH (ethanol)-induced inflammation in RAW264.7 cell line.
T0070907 or Benzamide has been used as a ADP-ribosyltransferase (ADPRT) inhibitor in rat hippocampal slices. It has also been used for urine analysis in patients diagnosed with acute uncomplicated urinary tract infection.

Actions biochimiques/physiologiques

T0070907 is very similar in structure and activity to the PPAR-γ antagonist GW9662. T0070907 is more potent and has higher selectivity for PPAR-γ over all other subtypes (about 800-fold) whereas GW9662 has been reported to have some PPAR-α agonist activity.

Caractéristiques et avantages

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Notes préparatoires

T0070907 is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

E M Schuman et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(25), 11958-11962 (1994-12-06)
Recent studies of long-term potentiation (LTP) in the CA1 region of the hippocampus have demonstrated that nitric oxide (NO) may be involved in some forms of LTP and have suggested that postsynaptically generated NO is a candidate to act as
Changsung Kim et al.
Nature, 494(7435), 105-110 (2013-01-29)
Cellular reprogramming of somatic cells to patient-specific induced pluripotent stem cells (iPSCs) enables in vitro modelling of human genetic disorders for pathogenic investigations and therapeutic screens. However, using iPSC-derived cardiomyocytes (iPSC-CMs) to model an adult-onset heart disease remains challenging owing
Sreedevi Avasarala et al.
Biology open, 2(7), 675-685 (2013-07-19)
In non-small cell lung cancer cell lines, activation of β-catenin independent signaling, via Wnt7a/Frizzled9 signaling, leads to reversal of cellular transformation, reduced anchorage-independent growth and induction of epithelial differentiation. miRNA expression profiling on a human lung adenocarcinoma cell line (A549)
T0070907, a PPAR gamma inhibitor, induced G2/M arrest enhances the effect of radiation in human cervical cancer cells through mitotic catastrophe
An Z, et al.
Reproductive Sciences, 21(11), 1352-1361 (2014)
Wogonin attenuates inflammation by activating PPAR-gamma in alcoholic liver disease
Li HD, et al.
International Immunopharmacology, 50, 95-106 (2017)
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