T7830

TFLLR-NH2 trifluoroacetate salt

>98% (HPLC)

• Synonyme(s) : L-Threonyl-L-phenylalanyl-L-leucyl-L-leucyl- L-argininamide trifluoroacetate salt, Thr-Phe-Leu-Leu-Arg-NH2 trifluoroacetate salt
• Formule empirique (notation de Hill): C₃₁H₅₃N₉O₆ · xC₂HF₃O₂
• Numéro CAS: 1313730-19-6
• Poids moléculaire : 647.81 (free base basis)
• Numéro MDL: MFCD05663482
• Code UNSPSC : 12352200
• ID de substance PubChem : 329826874
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: >98% (HPLC)
• Forme: lyophilized powder
• Couleur: white to tan
• Solubilité: H₂O: >2 mg/mL
• Température de stockage: −20°C
• Chaîne SMILES: OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
• InChI: 1S/C31H53N9O6.C2HF3O2/c1-17(2)14-22(27(43)37-21(26(33)42)12-9-13-36-31(34)35)38-28(44)23(15-18(3)4)39-29(45)24(16-20-10-7-6-8-11-20)40-30(46)25(32)19(5)41;3-2(4,5)1(6)7/h6-8,10-11,17-19,21-25,41H,9,12-16,32H2,1-5H3,(H2,33,42)(H,37,43)(H,38,44)(H,39,45)(H,40,46)(H4,34,35,36);(H,6,7)/t19-,21+,22+,23+,24+,25+;/m1./s1
• Clé InChI: QVNWOGSDGQDGHP-MKVNCOEFSA-N

Description

Amino Acid Sequence

Thr-Phe-Leu-Leu-Arg-NH2

Application

TFLLR-NH₂ trifluoroacetate salt has been used as a protease-activated receptor-1 (PAR-1) agonist to study its effects on hippocampal CA1 pyramidal neurons and Swell1 knock out mice (cKO).

Actions biochimiques/physiologiques

TFLLR-NH2 is a protease-activated receptor (PARs) agonist which is more selective to PAR-1 than SFLLRN-NH2. Protease-activated receptors (PARs) are present on various organs including, plateles, mast cell, gallblader, oesophagus etc, and regulate various physiological processes including human platelet aggregation, vascular contraction/relaxation, and an increase in endothelial permeability. Recent papers indicated that PAR′s are also involved in sensory processing. Specificly PAR ligands enhance glutamatergic excitatory transmission in substantia gelatinosa (SG) neurons of adult rat spinal cord slices.

Notes préparatoires

TFLLR-NH2 trifluoroacetate is soluble in water at a concentration that is greater than 2 mg/ml.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable