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Merck
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Key Documents

Autres documents

T5699

Sigma-Aldrich

m-3M3FBS

>97% (HPLC)

Synonyme(s) :

2,4,6-Trimethyl-N-(3-trifluoromethyl-phenyl)-benzenesulfonamide, N-(3-Trifluoromethylphenyl)-2,4,6-trimethylbenzenesulfonamide

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About This Item

Formule empirique (notation de Hill):
C16H16F3NO2S
Numéro CAS:
200933-14-8
Poids moléculaire :
343.36
Numéro MDL:
MFCD00095824
Code UNSPSC :
41106300
ID de substance PubChem :
329826829
Nomenclature NACRES :
NA.77

Pureté

>97% (HPLC)

Forme

powder

Couleur

white

Pf

114-114.8 °C (lit.)

Solubilité

DMSO: >20 mg/mL

Chaîne SMILES 

Cc1cc(C)c(c(C)c1)S(=O)(=O)Nc2cccc(c2)C(F)(F)F

InChI

1S/C16H16F3NO2S/c1-10-7-11(2)15(12(3)8-10)23(21,22)20-14-6-4-5-13(9-14)16(17,18)19/h4-9,20H,1-3H3

Clé InChI

ZIIUUSVHCHPIQD-UHFFFAOYSA-N

Application

m-3M3FBS has been used for MAP kinase assay in 293T cells. It has also been used for intracellular calcium analysis1. Furthermore, it has been used (at a conc. of 1 μM) as a PLC activator for sensitizing TRPA1 in HEK293t cells2.

Actions biochimiques/physiologiques

First known direct activator of phospholipase C (activates β2, β3, γ1, γ2, δ1 isoforms).

Notes préparatoires

m-3M3FBS is soluble in DMSO at a concentration that is greater than 20 mg/ml.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Alexander B Forster et al.
Molecular pain, 5, 17-17 (2009-04-18)
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Shih-Wei Wang et al.
Journal of cellular physiology, 236(5), 3979-3990 (2020-12-01)
Prostate cancer has high metastatic potential. Men with higher urinary levels of the sleep hormone melatonin are much less likely to develop advanced prostate cancer compared with men with lower levels of melatonin. Melatonin has shown anticancer activity in experimental
Jieny Gröper et al.
Cells, 9(4) (2020-04-29)
Ligand-based selectivity in signal transduction (biased signaling) is an emerging field of G protein-coupled receptor (GPCR) research and might allow the development of drugs with targeted activation profiles. Human formyl peptide receptor 1 (FPR1) is a GPCR that detects potentially
Ondrej Cerny et al.
Journal of immunology (Baltimore, Md. : 1950), 198(3), 1285-1296 (2017-01-01)
The adenylate cyclase toxin-hemolysin (CyaA) plays a key role in immune evasion and virulence of the whooping cough agent Bordetella pertussis. CyaA penetrates the complement receptor 3-expressing phagocytes and ablates their bactericidal capacities by catalyzing unregulated conversion of cytosolic ATP
Kathryn P Trogden et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(5), 2841-2854 (2018-02-07)
Vimentin is a cytoskeletal intermediate filament protein that is expressed in mesenchymal cells and cancer cells during the epithelial-mesenchymal transition. The goal of this study was to identify vimentin-targeting small molecules by using the Tocriscreen library of 1120 biochemically active
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