SRP8050

Profilin from Toxoplasma gondii

recombinant, expressed in E. coli, >95% (SDS-PAGE)

• Synonyme(s) : Inflammatory profilin, T Cell Membrane Protein 1
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: Toxoplasma gondii
• Produit recombinant: expressed in E. coli
• Pureté: >95% (SDS-PAGE)
• Forme: lyophilized
• Poids mol.: ~20 kDa by SDS-PAGE
• Conditionnement: pkg of 10 μg
• Conditions de stockage: avoid repeated freeze/thaw cycles
• Impuretés: <0.01 EU/μg endotoxin, tested
• Couleur: white
• Numéro d'accès UniProt: Q58NA1
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Informations sur le gène: Toxoplasma gondii ... PRF(7900190)

Description

Actions biochimiques/physiologiques

Profilin is a protozoan parasite protein. It activates toll-like receptor 11 (TLR11), which is an intracellular receptor localized on the endoplasmic reticulum (ER). TLR11 acts as an innate immune sensor for T. gondii profilin (TgPRF).The 12 membrane-spanning ER-resident protein UNC93B1 directly binds TLR11 and control the activation of dendritic cells in response to profilin (Toxoplasma gondii) and parasitic infection in vivo. TLR12 also has an ability to interact with (TgPRF). TLR12 is adequate for recognizing profilin in plasmacytoid dendritic cells (pDCs), whereas TLR11 and TLR12 are both needed in macrophages and conventional DCs. In contrast to TLR11, TLR12-deficient mice fail to resist T. gondii infection.

Forme physique

Lyophilized from PBS.

Reconstitution

Reconstitute with 100 μL deionized water.

Autres remarques

Recombinant profilin (Toxoplasma gondii) (aa 1-163).

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable