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Key Documents

SRP6519

Sigma-Aldrich

Lactoferrin from human milk

≥95% (SDS-PAGE)

Synonyme(s) :

Lactotransferrin, Talalactoferrin

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About This Item

Code UNSPSC :
12352202

Source biologique

human milk

Pureté

≥95% (SDS-PAGE)

Forme

frozen liquid

Poids mol.

82.4 kDa

Conditionnement

pkg of 10 mg

Technique(s)

ELISA: suitable

Numéro d'accès UniProt

4057

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... LTF(4057)

Description générale

Lactoferrin gene is mapped to human chromosome 3p21.31.
Lactoferrin is a glycoprotein present in exocrine secretions and in the secondary granules of polymorphonuclear neutrophils. It is the iron binding protein in milk. Human lactoferrin belongs to the family of transferrins. It is found to be expressed in several glandular epithelial cells and skin epidermal keratinocytes.

Application

Lactoferrin from human milk has been used as a standard in standard curve generation for quantifying recombinant lactoferrin in enzyme-linked immunosorbent assay (ELISA). It has also been used as a positive control in sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (PAGE ).

Actions biochimiques/physiologiques

Lactoferrin is known to regulate intestinal iron absorption, and to participate in the defense against bacteria. It functions in the innate immune system via the activation of nuclear factor-κB (NF-κB). This activation occurs via Toll-like receptor 4 pathway due to the interference of lactoferrin with the lipopolysaccharide-stimulated TLR4 signaling. It serves as a ligand for low-density lipoprotein receptor-related protein 1 (LRP1) in human skin keratinocytes and fibroblasts. It is capable of stimulating cell growth in various cell lines. Lactoferrin is also found to participate in wound healing.

Forme physique

Frozen in 50 mM Tris and 0.2 M NaCl, pH 8.0 .

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Protective factors in milk and the development of the immune system.
Hanson LA
Pediatrics, 75, 172-176 (1985)
L Tang et al.
The British journal of dermatology, 163(1), 38-47 (2010-03-13)
Human lactoferrin (hLF), a member of the transferrin family, is known for its antimicrobial and anti-inflammatory effects. Recent studies on various nonskin cell lines indicate that hLF may have a stimulatory effect on cell proliferation. To study the potential role
Effect of chloroquine on cultured fibroblasts: release of lysosomal hydrolases and inhibition of their uptake.
U N Wiesmann et al.
Biochemical and biophysical research communications, 66(4), 1338-1343 (1975-10-27)

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