SRP6518
Plasminogen from human plasma
≥95% (SDS-PAGE)
Synonyme(s) :
PLG
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About This Item
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32
Description générale
Plasminogen is the inactive precursor of plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration.
Plasminogen is encoded by the gene mapped to human chromosome 6q26–27. The encoded protein is characterized with a leader, kringle and protease domains.
Plasminogen is encoded by the gene mapped to human chromosome 6q26–27. The encoded protein is characterized with a leader, kringle and protease domains.
Actions biochimiques/physiologiques
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. It cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa. It activates matrix metalloproteinases by cleaving the inactive proenzymes. Plasmin is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β).
Forme physique
Lyophilized from 20 mM Tris-HCl, pH 7.5, with 2 mM EDTA.
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Three-dimensional micropatterning of bioactive hydrogels via two-photon laser scanning photolithography for guided 3D cell migration.
Lee SH, et al.
Biomaterials, 29, 2962-2968 (2008)
Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D.
McColl BK, et al.
The Journal of Experimental Medicine, 198, 863-868 (2003)
Genetic linkage between lipoprotein (a) phenotype and a DNA polymorphism in the plasminogen gene.
Drayna D T, et al.
Genomics, 3(3), 230-236 (1988)
Minor Role of Plasminogen in Complement Activation on Cell Surfaces.
Hyvarinen S and Jokiranta TS
PLoS ONE, 10, e0143707-e0143707 (2015)
Nitrosothiol formation catalyzed by ceruloplasmin. Implication for cytoprotective mechanism in vivo.
Inoue K, et al.
The Journal of Biological Chemistry, 274, 27069-27075 (1999)
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