SRP6282

Nicotinamide N-Methyltransferase (hNNMT) human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

• Synonyme(s) : NNMT
• Code UNSPSC : 12352204
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: human
• Produit recombinant: expressed in E. coli
• Pureté: ≥98% (SDS-PAGE)
• Forme: liquid
• Poids mol.: 31.7 kDa (263 aa + NT 6xHis-tag)
• Conditionnement: pkg of 1 mg; pkg of 100 μg; pkg of 20 μg
• Concentration: 3.42 mg/mL
• Numéro d'accès UniProt: P40261
• Conditions d'expédition: dry ice
• Température de stockage: −70°C
• Informations sur le gène: human ... NNMT(4837)

Description

Description générale

N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. NNMT is an important cytosolic methyltransferase catalyzing the N-methylation of nicotinamide, pyridines and structural analogs, playing a crucial role in the biotransformation and detoxification of many xenobiotic compounds. In the N-methylation process, NNMT uses S-adenosyl methionine as the methyl donor and nicotinamide as methyl acceptor. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. It may also play an important role in regulating biological processes related to N-methyl nicotinamide such as anti-inflammatory, anti-thrombotic, vasoprotective, and gastroprotective properties. Increased NNMT activity was reported in many kinds of tumors. NNMT is a potential biomarker and therapeutic target in caner diagnosis and treatment. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer. The recombinant protein includes hNNMT with N-terminal His-tag.

Forme physique

3.42 mg/mL solution in 25 mM Tris (pH8.0) buffer containing 20% glycerol.

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable