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Key Documents

SRP4869

Sigma-Aldrich

Placental Lactogen human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

Synonyme(s) :

CSA, CSH1, CSH2, CSMT, FLJ75407, PL

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About This Item

Numéro MDL:
MFCD00131483
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.32

Source biologique

human

Produit recombinant

expressed in E. coli

Pureté

≥95% (HPLC)
≥95% (SDS-PAGE)

Forme

lyophilized

Poids mol.

~22.3 kDa

Conditionnement

pkg of 20 μg

Conditions de stockage

avoid repeated freeze/thaw cycles

Technique(s)

cell based assay: suitable

Impuretés

endotoxin, tested

Numéro d'accès NCBI

P01243

Numéro d'accès UniProt

Q6PF11

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

human ... CSH1(1442)

Description générale

Human placental lactogen (HPL), also called human chorionic somatomammotropin 1, is a polypeptide placental hormone. Its structure and function is similar to that of growth hormone. The gene encoding this protein is localized on human chromosome 17. Recombinant human placental lactogen is a 22.3kDa protein.

Actions biochimiques/physiologiques

Human placental lactogen (HPL) modifies the metabolic state of the mother during pregnancy to facilitate the energy supply, glucose supply and growth of the fetus. Studies show that targeted expression of this protein in transgenic mice lead to an increase in proliferation of β-cells.

Forme physique

Sterile filtered and lyophilized with no additives.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Placental lactogen is expressed but is not translated into protein in breast cancer.
Tuttle TR
PLoS ONE, 9(1), e87325-e87325 (2014)
Meltem Muftuoglu et al.
Nucleic acids research, 34(1), 295-304 (2006-01-18)
Cockayne syndrome (CS) is a rare inherited human genetic disorder characterized by UV sensitivity, severe neurological abnormalities and prageroid symptoms. The CS complementation group B (CSB) protein is involved in UV-induced transcription coupled repair (TCR), base excision repair and general
A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population.
Freathy RM
Journal of Negative Results in Biomedicine, 5, 18-18 (2006)
Zinuo Chen et al.
Cell & bioscience, 11(1), 45-45 (2021-03-01)
In the urgent campaign to develop therapeutics against SARS-CoV-2, natural products have been an important source of new lead compounds. We herein identified two natural products, ginkgolic acid and anacardic acid, as inhibitors using a high-throughput screen targeting the SARS-CoV-2
Marco F Lombardo et al.
Islets, 3(5), 250-258 (2011-07-19)
The search for factors either promoting islets proliferation or survival during adult life is a major issue for both type 1 and 2 diabetes mellitus. Among factors with mitogenic activity on pancreatic β-cells, human placental lactogen (hPL) showed stronger activity

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