SML3750

SR-302

≥98% (HPLC)

• Synonyme(s) : N-(4-(((S)-4-Cyclohexyl-1-(((SR)-1-(methylsulfonyl)piperidin-3-yl)amino)-1-oxobutan-2-yl)carbamoyl)benzyl)imidazo[1,2-a]-pyridine-3-carboxamide, N-(4-((2S)-4-Cyclohexyl-1-(1-(methylsulfonyl)piperidin-3-ylamino)-1-oxobutan-2-ylcarbamoyl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide, SR 302, SR302
• Formule empirique (notation de Hill): C₃₂H₄₂N₆O₅S
• Numéro CAS: 2771319-74-3
• Poids moléculaire : 622.78
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.21

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 2 mg/mL, clear
• Température de stockage: -10 to -25°C
• Chaîne SMILES: O=C(NCC1=CC=C(C=C1)C(N[C@H](C(NC2CN(CCC2)S(=O)(C)=O)=O)CCC3CCCCC3)=O)C4=CN=C5C=CC=CN54
• InChI: 1S/C32H42N6O5S/c1-44(42,43)37-18-7-10-26(22-37)35-31(40)27(17-14-23-8-3-2-4-9-23)36-30(39)25-15-12-24(13-16-25)20-34-32(41)28-21-33-29-11-5-6-19-38(28)29/h5-6,11-13,15-16,19,21,23,26-27H,2-4,7-10,14,17-18,20,22H2,1H3,(H,34,41)(H,35,40)(H,36,39)/t26?,27-/m
• Clé InChI: WGMNFJAFXXXRLZ-GEVKEYJPSA-N

Description

Actions biochimiques/physiologiques

Potent ATP-competitive inhibitor against DDR1, DDR2; MAPK11 (p38β), and MAPK14 (p38α) with good cellular target actviity and kinome selectivity.

SR-302 is an ATP-competitive, potent and selective inhibitor against DDR1/2 & MAPK11/14 (IC50/[ATP] = 53.3 nM/100 μM/DDR1, 0.75 nM/5 μM/DDR2; 45.1 nM/50 μM/MAPK11 (p38β), 6.2 nM/2.5 μM/MAPK14 (p38α) by cell-free kinase assay) with good cellular target actviity (IC50 = 18 nM/DDR2, 23 nM/DDR1, 125 nM/MAPK14, 196 nM/MAPK11 by NanoBRET) and kinome selectivity.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable