SML3722

Dinaciclib

≥98% (HPLC)

• Synonyme(s) : (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol, 2-[(2S)-1-[3-Ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol, MK 7965, MK-7965, MK7965, SCH 727965, SCH-727965, SCH727965
• Formule empirique (notation de Hill): C₂₁H₂₈N₆O₂
• Numéro CAS: 779353-01-4
• Poids moléculaire : 396.49
• Numéro MDL: MFCD16037702
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.21

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: , White to light brown
• Solubilité: DMSO: 2 mg/mL, clear
• Température de stockage: -10 to -25°C
• Chaîne SMILES: [n+]1(cc(ccc1)CNC2=CC(=Nc4[n]2ncc4CC)N3[C@@H](CCCC3)CCO)[O-]
• Clé InChI: PIMQWRZWLQKKBJ-SFHVURJKSA-N

Description

Actions biochimiques/physiologiques

Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor (CDK1/2/5/6/7/9 IC50 = 3/1/1/12/7/4 nM; Little or no inhibition of 41 other kinases at 10 μM) with potent antiproliferation activity in A2780 ovarian cancer cultures (IC50 = 4 nM by thymidine uptake assays). Dinaciclib exhibits potent anti-cancer efficacy in cultures (IC50 = 6-17 nM against 14 cancer cell lines) and in an A2780 tumor xenograft model in mice in vivo (8-48 mg/kg via daily i.p.).

Potent and selective cyclin-dependent kinase (CDK) inhibitor with potent anti-cancer efficacy in cultures and in mice in vivo.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable