SML3679

SLM6031434 hydrochloride

≥98% (HPLC)

• Synonyme(s) : (2S)-2-[3-[4-(Octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide, hydrochloride, (S)-2-(3-(4-(Octyloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide, hydrochloride, (S)-Amino(2-(3-(4-(octyloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)methaniminium chloride, SLM 6031434 HCl, SLM 6081442 (S)-enantiomer HCl, SLM-6031434 HCl, SLM-6081442 (S)-enantiomer HCl, SLM6081442 (S)-enantiomer HCl
• Formule empirique (notation de Hill): C₂₂H₃₀F₃N₅O₂·HCl
• Numéro CAS: 1897379-34-8
• Poids moléculaire : 489.96
• Numéro MDL: MFCD31689247
• Code UNSPSC : 51111800
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.21

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: water: ≥2 mg/mL
• Température de stockage: -10 to -25°C

Description

Actions biochimiques/physiologiques

SLM6031434 is a selective sphingosine (Sph) kinase 2 (SK2, SphK2, SpK2) inhibitor (r/m SphK2 Ki = 400/500 nM, r/m SphK1 Ki >20 μM) that effectively downregulates cellular sphingosine 1-phosphate (S1P) level (47% S1P & 143% Sph of control in U937 post 2h 100 nM SLM6031434 treatment) and selectively reduces plasma S1P in Sphk1-/-, but not Sphk2-/- mice in vivo (5 mg/kg i.v.). In contrary to Sphk2-KO mice, SLM6031434 treatment enhances plasma S1P in wild-type mice and offers neuroprotective efficacy against ischemic stroke (2 mg/kg i.v. 2h prior to tMCAO).

Attention

Hygroscopic

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable