Accéder au contenu
Merck
Toutes les photos(1)

Documents

SML2082

Sigma-Aldrich

Scrambled 10Panx1 trifluoroacetate salt

≥98% (HPLC)

Synonyme(s) :

10PanxSCR TFA, FSVYWAQADR TFA, L-phenylalanyl-L-seryl-L-valyl-L-tyrosyl-L-tryptophyl-L-alanyl-L-glutaminyl-L-alanyl-L-a-aspartyl-L-arginine TFA, Phe-Ser-Val-Tyr-Trp-Ala-Gln-Ala-Asp-Arg TFA, SCPanx, TFA, Scrambled 10Panx TFA

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Formule empirique (notation de Hill):
C58H79N15O16 · xC2HF3O2
Numéro CAS:
1315378-72-3
Poids moléculaire :
1242.34 (free base basis)
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

film (Colorless)

Couleur

white to off-white

Conditions d'expédition

wet ice

Température de stockage

−20°C

InChI

1S/C58H79N15O16/c1-29(2)47(73-55(86)44(28-74)72-50(81)37(59)23-32-11-6-5-7-12-32)56(87)71-41(24-33-16-18-35(75)19-17-33)53(84)70-42(25-34-27-64-38-14-9-8-13-36(34)38)52(83)66-30(3)48(79)67-39(20-21-45(60)76)51(82)65-31(4)49(80)69-43(26-46(77)78)54(85)68-40(57(88)89)15-10-22-63-58(61)62/h5-9,11-14,16-19,27,29-31,37,39-44,47,64,74-75H,10,15,20-26,28,59H2,1-4H3,(H2,60,76)(H,65,82)(H,66,83)(H,67,79)(H,68,85)(H,69,80)(H,70,84)(H,71,87)(H,72,81)(H,73,86)(H,77,78)(H,88,89)(H4,61,62,63)

Clé InChI

VNQGVHMGXBRHRA-UHFFFAOYSA-N

Actions biochimiques/physiologiques

SCPanx (10PanxSCR) corresponds to the scrambled version of the pannexin-1 (panx1) inhibitor peptide 10panx1 and serves as a negative control peptide in pannexin-1 inhibitory studies involving 10panx1 treatment both in vitro and in vivo.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Paul W Furlow et al.
Nature cell biology, 17(7), 943-952 (2015-06-23)
During metastatic progression, circulating cancer cells become lodged within the microvasculature of end organs, where most die from mechanical deformation. Although this phenomenon was first described over a half-century ago, the mechanisms enabling certain cells to survive this metastasis-suppressive barrier
Stephani Velasquez et al.
Journal of immunology (Baltimore, Md. : 1950), 196(10), 4338-4347 (2016-04-15)
Pannexin1 (Panx1) channels are large high conductance channels found in all vertebrates that can be activated under several physiological and pathological conditions. Our published data indicate that HIV infection results in the extended opening of Panx1 channels (5-60 min), allowing
Juan Mauricio Garré et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(17), 4785-4801 (2016-04-29)
We show here that the growth factor FGF-1 is proinflammatory in the spinal cord and explore the inflammatory mechanisms. FGF-1 applied to rat spinal astrocytes in culture initiates calcium signaling and induces secretion of ATP that within minutes increases membrane
Philipp Prager et al.
PloS one, 11(10), e0165653-e0165653 (2016-10-28)
Systemic hypertension is a risk factor of age-related macular degeneration (AMD), a chronic inflammatory disease. Acute hypertension is caused by increased extracellular osmolarity after intake of dietary salt (NaCl). We determined in cultured human retinal pigment epithelial (RPE) cells whether
Nicholas L Weilinger et al.
Nature neuroscience, 19(3), 432-442 (2016-02-09)
Overactivation of neuronal N-methyl-D-aspartate receptors (NMDARs) causes excitotoxicity and is necessary for neuronal death. In the classical view, these ligand-gated Ca(2+)-permeable ionotropic receptors require co-agonists and membrane depolarization for activation. We report that NMDARs signal during ligand binding without activation
Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique