SML1813

Ani9

• Synonyme(s) : (4-Chloro-2-methylphenoxy)-acetic acid [(2-methoxyphenyl)methylene]hydrazide, 2-(4-Chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)methylideneamino]-acetamide, 2-(4-Chloro-2-methylphenoxy)-acetic acid 2-[(2-methoxyphenyl)methylene]hydrazide
• Formule empirique (notation de Hill): C₁₇H₁₇ClN₂O₃
• Numéro CAS: 356102-14-2
• Poids moléculaire : 332.78
• Code UNSPSC : 12352200
• ID de substance PubChem : 329826081
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Niveau de qualité: 100
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 25 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: CC1=C(OCC(NN=CC2=C(OC)C=CC=C2)=O)C=CC(Cl)=C1

Description

Application

Ani9 has been used to find out the inappropriate modulation of the membrane protein functions that are involved in the 198 ADGRG2- or Gq-mediated regulation of fluid reabsorption in the efferent ductules.

Actions biochimiques/physiologiques

2-(4-chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)methylideneamino]-acetamide (Ani9), the most potent inhibitor, is the structural analog of Ani7. It may be considered as a novel candidate for drug therapy of cancer, hypertension, pain, diarrhea and asthma.

Ani9 is a potent and highly selective anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A) inhibitor that completely inhibited ANO1 chloride current with submicromolar potency. Ani9 does not affect the intracellular calcium signaling and CFTR chloride channel activity.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3