SML1739

CX08005

≥98% (HPLC)

• Synonyme(s) : 2-(((2-(Tetradecyloxy)phenyl)amino)carbonyl)benzoic acid
• Formule empirique (notation de Hill): C₂₈H₃₉NO₄
• Numéro CAS: 1256341-22-6
• Poids moléculaire : 453.61
• Code UNSPSC : 12352200
• ID de substance PubChem : 329826047
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 20 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C(O)C1=C(C(NC2=C(OCCCCCCCCCCCCCC)C=CC=C2)=O)C=CC=C1

Description

Actions biochimiques/physiologiques

CX08005 is a cell-permeable benzoic acid based compound, potent and substrate-competitive PTP1B/TCPTP dual inhibitor with anti-diabetic efficacy both in vitro and in vivo. CX08005 targets protein tyrosine phosphatase 1B (PTP1B) catalytic P-loop and acts as a substrate-competitive inhibitor against PTP1B and TCPTP (IC₅₀ = 781 and 475 nM, respectively) with much reduced potency toward LAR, SHP1, and VHR (by 52%, 89%, and 60%, respectively, at 10 μM). CX08005 enhances insulin-dependent cellular signaling (Eff. conc. 10 nM; HepG2 cells) and glucose uptake (Eff. conc. 100-500 nM; 3T3-L1 adipocityes and C2C12 myoblasts) in vitro, as well as improves glucose tolerance and insulin sensitivity in diet-induced obesity (DIO) mice and KKAy type 2 diabetes mice (50-200 mg/kg/day i.p.) in vivo with good pharmacokinetics in SD rats (C_max = 7425.9 ng/mL, T_max = 6.67 h,  t_1/2 = 2.5 h).

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable