SML1467

ASP7663

≥98% (HPLC)

• Synonyme(s) : (2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid, (E)-[7-Fluoro-1-(2-methylpropyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]acetic acid
• Formule empirique (notation de Hill): C₁₄H₁₄FNO₃
• Numéro CAS: 1190217-35-6
• Poids moléculaire : 263.26
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825901
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: light orange to dark orange
• Solubilité: DMSO: 25 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: CC(C)CN(C1=C(F)C=CC=C1/C2=C\C(O)=O)C2=O
• InChI: 1S/C14H14FNO3/c1-8(2)7-16-13-9(4-3-5-11(13)15)10(14(16)19)6-12(17)18/h3-6,8H,7H2,1-2H3,(H,17,18)/b10-6+
• Clé InChI: RCVZUIGCNAAMIC-UXBLZVDNSA-N

Description

Actions biochimiques/physiologiques

ASP7663 is a selective activator of transient receptor potential ankyrin 1 (TRPA1), known to play a role for chemical sensing in the pain pathway. ASP7663 activated human, rat, and mouse TRPA1 receptors with EC₅₀ values of 510, 540, and 500 nM, respectively, and little or no affinity at more than 60 other related receptors, channels and enzymes. ASP7663 enhanced colonic motility and exerted analgesic effects against abdominal pain in mouse models.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable