SMB01024

Diuvaretin

≥90% (LC/MS-ELSD)

• Synonyme(s) : 1-[2,4-dihydroxy-3,5-bis[(2-hydroxyphenyl)methyl]-6-methoxyphenyl]-3-phenylpropan-1-one
• Formule empirique (notation de Hill): C₃₀H₂₈O₆
• Numéro CAS: 61463-04-5
• Poids moléculaire : 484.54
• Numéro MDL: MFCD18975655
• Code UNSPSC : 12352205
• Nomenclature NACRES : NA.25

Propriétés

• Source biologique: plant
• Pureté: ≥90% (LC/MS-ELSD)
• Forme: solid
• Poids mol.: 484.54
• Solubilité: water: slightly soluble
• Application(s): metabolomics; vitamins, nutraceuticals, and natural products
• Température de stockage: −20°C
• InChI: 1S/C30H28O6/c1-36-30-23(18-21-12-6-8-14-25(21)32)28(34)22(17-20-11-5-7-13-24(20)31)29(35)27(30)26(33)16-15-19-9-3-2-4-10-19/h2-14,31-32,34-35H,15-18H2,1H3
• Clé InChI: KDEMELRYKGOXDL-UHFFFAOYSA-N

Description

Description générale

Diuvaretin, a dihydrochalcone, is a natural product commonly available from Dipteryx odorata, Uvaria acuminata and Uvaria chamae plants. This plant metabolite exhibits various biological activities such as anti-inflammatory, antioxidant, antineoplastic, anti-angiogenic, and antimalarial properties.

Application

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Actions biochimiques/physiologiques

Diuvaretin exhibits cytotoxicity towards human promyelocytic leukemia HL-60 cells. It has a role as a metabolite, an antineoplastic agent and an antimalarial.

Diuvaretin inhibits NF-kB activation, hindering inflammation and cancer. It also suppresses tumor cell proliferation, induces apoptosis, and diminishes tumor growth and angiogenesis in mouse cancer models.

Caractéristiques et avantages

• High quality compound suitable for multiple research applications
• Compatible with HPLC and mass spectrometry techniques

Autres remarques

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable