SCP0170

Granulocyte Elastase Substrate human

≥95% (HPLC), lyophilized

• Formule empirique (notation de Hill): C₂₁H₂₇N₅O₆
• Poids moléculaire : 445.47
• Code UNSPSC : 12352204
• Nomenclature NACRES : NA.32

Propriétés

• Nom du produit: Granulocyte Elastase Substrate human,
• Essai: ≥95% (HPLC)
• Forme: lyophilized
• Composition: Peptide Content, ≥85%
• Conditions de stockage: protect from light
• Température de stockage: −20°C

Description

Amino Acid Sequence

Glp-Pro-Val-pNA

Description générale

Elastase, a glycoprotein, is a member of the serine proteases family. It is synthesized by human polymorphonuclear (PMN) leukocytes or by the pancreas. Human granulocyte elastase is liberated in large amounts from granulocytes in chronic inflammatory joint disorders.

Actions biochimiques/physiologiques

Elastase is a catalytic enzyme that catalyzes the cleavage of carboxyl groups on tiny hydrophobic amino acids including glycine, alanine, and valine. Its main function is to break down elastin. Free elastase in some purulent synovial fluids plays a key role in articular cartilage breakdown. Increased elastase levels in the plasma have been seen in patients with evident rheumatoid arthritis.

Elastase(s) can be assayed and differentiated using chromogenic and fluorogenic Pro-Val peptide substrates such as Glp-Pro-Val-pNA and MeOSuc-Ala-Ala-Pro-Val-4-MNA.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable