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Key Documents

SAB5600038

Sigma-Aldrich

Anti-Gamma H2AX (phospho-Ser139) antibody, Rabbit monoclonal

recombinant, expressed in HEK 293 cells, clone RM224, purified immunoglobulin

Synonyme(s) :

H2AX Ser139 p, Histone H2AX (phospho ser139)

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Produit recombinant

expressed in HEK 293 cells

Niveau de qualité

100

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

RM224, monoclonal
recombinant monoclonal

Forme

buffered aqueous glycerol solution

Espèces réactives

human

Concentration

~1 mg/mL

Technique(s)

ELISA: 0.2- 1  μg/mL
immunoblotting: 0.5-2 μg/mL
immunocytochemistry: 0.5-2 μg/mL

Isotype

IgG

Numéro d'accès NCBI

3014

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pSer139)

Informations sur le gène

human ... H2AX(3014)

Description générale

Histone H2AX (H2A histone family member X), a histone variant present in almost all eukaryotes, is coded by H2AFX gene. It is mapped to human chromosome 11q23.2–11q23.3.

Spécificité

This antibody reacts to Histone H2A.X only when phosphorylated at serine 139. No cross reactivity with other phosphorylated histones.

Immunogène

Synthetic peptide corresponding to Phospho-Histone H2AX (Ser139)

Actions biochimiques/physiologiques

H2AX (H2A histone family member X) helps to maintain genome stability. It plays an important role in localisation and structuring of the repair focus. H2AX also plays an active role in supplying the active repair proteins. γH2AX participates in DSB repair. This protein serves as a signal and target of phosphorylation in the spreading phase.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Genome Stability and Human Diseases (2010)
Dong Luo et al.
ACS applied materials & interfaces, 14(13), 14916-14927 (2022-03-23)
Combined radiotherapy (RT) and chemotherapy are prescribed to patients with advanced prostate cancer (PCa) to increase their survival; however, radiation-related side effects and systematic toxicity caused by chemotherapeutic drugs are unavoidable. To improve the precision and efficacy of concurrent RT
Gulam Mohmad Rather et al.
Cancers, 13(5) (2021-03-04)
We tested the antitumor effects of a modified E2F peptide substituting D-Arg for L-Arg, conjugated to penetratin (PEP) against solid tumor cell lines and the CCRF-leukemia cell line, alone and in combination with pemetrexed or with cisplatin. For in-vivo studies

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