SAB5500188

Anti-URI antibody, Rabbit monoclonal

recombinant, expressed in proprietary host, clone SP215, affinity isolated antibody

• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41
• Conjugué: unconjugated
• application: FACS; IHC
• Clone: SP215, monoclonal
• Espèces réactives: human (tested)
• Technique(s): flow cytometry: 1:100; immunohistochemistry: 1:100

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Produit recombinant: expressed in proprietary host
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: SP215, monoclonal
• Espèces réactives: human (tested)
• Réactivité de l'espèce (prédite par homologie): bovine, mouse
• Technique(s): flow cytometry: 1:100; immunohistochemistry: 1:100
• Isotype: IgG
• Numéro d'accès UniProt: O94763
• Conditions d'expédition: wet ice
• Température de stockage: 2-8°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... URI1(8725)

Description

Description générale

Unconventional prefoldin RPB5 interactor (URI) is an oncogene required for the survival of some human carcinomas and is often amplified and over-expressed in subsets of carcinomas from ovary, breast, stomach, and lung. Activation of URI contributes an important mechanism for activating mitochondrial S6K1-BAD signaling and promoting cell survival through disabling PP1γ-dependent negative feedback inhibition. URI can negatively modulate RNA polymerase II subunit 5 (RPB5) and mediates resistance of cells to cisplatin.

Immunogène

Synthetic peptide derived from the C-terminus of the human URI protein.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable