SAB5200049
Monoclonal Anti-GABRB3 antibody produced in mouse
clone S87-25, 1 mg/mL, purified immunoglobulin
Synonyme(s) :
Anti-GABA(A) receptor subunit beta3, Anti-GABAAR Beta3, S87-25, Anti-Gabrb3
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Source biologique
mouse
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
S87-25, monoclonal
Forme
buffered aqueous glycerol solution
Poids mol.
antigen predicted mol wt 55 kDa
Espèces réactives
human, mouse, rat
Concentration
1 mg/mL
Technique(s)
immunocytochemistry: suitable
western blot: suitable
Isotype
IgG1
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
mouse ... Gabrb3(14402)
Description générale
The γ-aminobutyric acid type A receptor β3 subunit (GABRB3) gene with nine exons spanning 250kb, is mapped to human chromosome 15q12, a hot region of genomic rearrangements. The gene codes for β3 subunit of GABAA receptor, which belongs to the GABA (γ-aminobutyric acid) receptor gene family.
Spécificité
Detects ~55 kDa. No cross-reactivity against GABA-A-R-Beta 2 or –Beta1.
Immunogène
Fusion protein amino acids 370-433 of mouse GABA-A_r Beta3, Accession Number AAB60502.
Actions biochimiques/physiologiques
γ-aminobutyric acid type A receptor β3 subunit (GABRB3) is a candidate gene for autism spectrum conditions (ASC). Alteration in the gene results in increased tactile sensitivity, or hypersensitivity. Overexpression of GABRB3 might be implicated in the pathogenesis of heroin dependence. Aberration or mutation of this gene leads to neurodevelopmental disorders, such as Angelman syndrome, Prader-Willi syndrome and schizophrenia. GABRB3 polymorphisms results in nonsyndromic cleft lip and/or palate (NSCL/P).
Caractéristiques et avantages
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Forme physique
Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Teresa Tavassoli et al.
Molecular autism, 3(1), 6-6 (2012-07-10)
Autism spectrum conditions have a strong genetic component. Atypical sensory sensitivities are one of the core but neglected features of autism spectrum conditions. GABRB3 is a well-characterised candidate gene for autism spectrum conditions. In mice, heterozygous Gabrb3 deletion is associated
Paul Hoerbelt et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(8), 3525-3536 (2015-02-27)
Dopamine is a critical neuromodulator that activates GPCRs in mammals or ligand-gated ion channels in invertebrates. The present study demonstrates that dopamine (0.1-10 mm) exerts novel, opposing effects on different populations of mammalian (rat) GABAA receptors. Using whole-cell patch-clamp electrophysiology
Chia-Chun Huang et al.
Psychiatric genetics, 24(4), 151-157 (2014-05-29)
Copy number variations encompassing the chromosome 15q11-q13 region have been implicated in the pathogenesis of several neurodevelopmental disorders including schizophrenia. The study aimed to investigate whether the GABRB3 gene mapped to 15q12 was associated with schizophrenia. We resequenced the promoter
Chia-Hsiang Chen et al.
PloS one, 9(7), e102227-e102227 (2014-07-16)
GABRB3 encoding the β3 subunit of GABAA receptor has been implicated in multiple neuropsychiatric disorders, including substance abuse. Previous studies reported that SNPs at the 5' regulatory region of GABRB3 could regulate GABRB3 gene expression and associated with childhood absence
J Wagstaff et al.
American journal of human genetics, 49(2), 330-337 (1991-08-11)
Deletions of the proximal long arm of chromosome 15 (bands 15q11q13) are found in the majority of patients with two distinct genetic disorders, Angelman syndrome (AS) and Prader-Willi syndrome (PWS). The deleted regions in the two syndromes, defined cytogenetically and
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