SAB4700005
Monoclonal Anti-CD95 antibody produced in mouse
clone LT95, purified immunoglobulin, buffered aqueous solution
Synonyme(s) :
Anti-FAS
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
LT95, monoclonal
Forme
buffered aqueous solution
Espèces réactives
human
Concentration
1 mg/mL
Technique(s)
flow cytometry: suitable
Isotype
IgG1
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
2-8°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... FAS(355)
Catégories apparentées
Description générale
CD95, also known as Fas (fatty acid synthase) cell surface death receptor/APO-1, is encoded by the gene mapped to human chromosome 10q23.31. The encoded protein belongs to the tumor necrosis factor receptor superfamily and is expressed on a variety of cells including activated T and B cells. CD95 contains a death domain.
The antibody LT95 reacts with CD95 (Fas/APO-1), a 46 kDa single chain type I glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells. It seems that the antibody LT95 does not induce Fas mediated apoptosis, although it cross-blocks anti-Fas DX2 antibody that recognizes a functional epitope of Fas molecule.
Immunogène
HUT-78 human T cell lymphoma cell line
Application
Monoclonal Anti-CD95 antibody produced in mouse has been used as a apoptosis inducer.
Actions biochimiques/physiologiques
CD95/ Fas (fatty acid synthase) cell surface death receptor interacts with its natural ligand (FasL/CD95 L) and plays a vital role in regulation of T-cell homeostasis, by promoting apoptosis via activation-induced cell death (AICD). Mutation in the gene has been associated with the development of Sézary syndrome (SS) and Canale–Smith syndrome. CD95 gene loss can be used as a genetic marker of PSA recurrence after radical prostatectomy.
Caractéristiques et avantages
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Forme physique
Solution in Tris buffered saline, pH 8.0, with 15 mM sodium azide.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Downregulation of Fas Gene Expression in Sezary Syndrome Is Associated with Promoter Hypermethylation
Jones CL
The Journal of Investigative Dermatology, 130, 1116-1125 (2010)
Chlorpyrifos and Cypermethrin Induce Apoptosis in Human Neuroblastoma Cell Line SH-SY5Y
Raszewski G
Basic and Clinical Pharmacology and Toxicology, 116, 158-167 (2015)
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.
Kischkel FC
The Embo Journal, 14, 5579-5588 (1995)
Exploring prostate cancer genome reveals simultaneous losses of PTEN, FAS and PAPSS2 in patients with PSA recurrence after radical prostatectomy.
Ibeawuchi C
International Journal of Molecular Sciences, 16, 3856-3869 (2015)
Katrin A Salva et al.
Photochemistry and photobiology, 94(5), 1058-1065 (2018-04-21)
Aminolevulinate-based photodynamic therapy (ALA-PDT) selectively eliminates diseased tissues primarily through the induction of intrinsic apoptotic pathway. ALA-PDT is a first-line therapy for actinic keratosis, however, it is less effective for cutaneous T-cell lymphoma (CTCL). We have previously demonstrated that the
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