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Key Documents

SAB4503872

Sigma-Aldrich

Anti-phospho-Fyn (pTyr530) antibody produced in rabbit

affinity isolated antibody

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 60 kDa

Espèces réactives

rat, human, mouse

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

P06241

Numéro d'accès UniProt

P06241

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pTyr530)

Informations sur le gène

human ... FYN(2534)

Description générale

Tyrosine-protein kinase FYN is a neuronally enriched cytoplasmic protein. It is encoded by the genes mapped to human chromosome 6q21. FYN protein belongs to the proto-oncogene tyrosine-protein kinase, Src family.

Immunogène

The antiserum was produced against synthesized peptide derived from human Fyn around the phosphorylation site of Tyr530.

Immunogen Range: 488-537

Application

Anti-phospho-Fyn (pTyr530) antibody produced in rabbit has been used in immunoprecipitation and immunoblotting.

Actions biochimiques/physiologiques

Tyrosine-protein kinase FYN and phospho-FYN act as signaling systems for spatial memory. Phospho-FYN plays a vital role in the regulation of oligodendrocyte myelination and neurofilament phosphorylation. FYN aids in the development and activation of T cells in various physiological conditions. Overexpression of the FYN gene has been observed in various types of cancer.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Matthias Schmitz et al.
Molecular neurobiology, 50(3), 923-936 (2014-03-08)
The cellular prion protein (PrPC) is a highly conserved protein whose exact physiological role remains elusive. In the present study, we investigated age-dependent behavioral abnormalities in PrPC-knockout (Prnp0/0) mice and wild-type (WT) controls. Prnp0/0 mice showed age-dependent behavioral deficits in
Yuta Shimanaka et al.
Nature medicine, 23(11), 1287-1297 (2017-10-17)
Critical to the function of mast cells in immune responses including allergy is their production of lipid mediators, among which only omega-6 (ω-6) arachidonate-derived eicosanoids have been well characterized. Here, by employing comprehensive lipidomics, we identify omega-3 (ω-3) fatty acid
Haley Peckham et al.
Glia, 64(2), 255-269 (2015-10-10)
Fyn, a member of the Src family of nonreceptor tyrosine kinases, promotes central nervous system myelination during development; however the mechanisms mediating this effect remain unknown. Here we show that Fyn phosphorylation is modulated by BDNF in vivo. Concordant with

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