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Key Documents

SAB4503369

Sigma-Aldrich

Anti-Calcium Sensing Receptor antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

CASR, CaSR, Extracellular calcium-sensing receptor, PCaR1, Parathyroid Cell calcium-sensing receptor

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About This Item

Numéro MDL:
MFCD02262635
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 120 kDa

Espèces réactives

human, mouse, rat

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

P41180

Numéro d'accès UniProt

P41180

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CASR(846)

Description générale

Anti-Calcium Sensing Receptor Antibody detects endogenous levels of total Calcium Sensing Receptor protein.
The calcium sensing receptor (CASR) is a 1078 amino acid protein. It has 11 exons and is located on human chromosome 3q13.33-q21.1. CASR belongs to the C family of G protein–coupled receptors. It is located in the parathyroid gland and the thick ascending limb of the Henle loop.

Immunogène

The antiserum was produced against synthesized peptide derived from human Calcium Sensing Receptor.

Immunogen Range: 854-903

Actions biochimiques/physiologiques

Calcium sensing receptor (CASR) modulates the activities of cells according to the extracellular calcium concentration. It also plays a major role in controlling parathyroid hormone (PTH) secretion. CASR has a vital role in signal transduction pathways in various tissues like parathyroid gland, kidney, gastrointestinal tract, placenta, pancreas and brain. Mutation in the gene is linked with autosomal dominant hypocalcemic, hypercalciuria and Bartter syndrome.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Genetic Risk Factors for Idiopathic Urolithiasis: A Systematic Review of the Literature and Causal Network Analysis
Taguchi K, et al.
European eurology focus, 3(1), 72-81 (2017)
Calcium-Sensing Receptors
Goodman WG.
Seminars in Nephrology, 24 (2004)
Elena Dyukova et al.
Journal of cellular physiology, 232(9), 2508-2518 (2016-09-24)
Nitric oxide (NO)-deficiency as it occurs during endothelial dysfunction activates the endothelin-1 (ET-1) system and increases the expression of receptor activity modifying protein (RAMP)-1 that acts as a chaperon for calcium-sensing receptors (CaR) that have recently been identified to improve
Guoliang Zhang et al.
Aging, 11(19), 8313-8328 (2019-10-03)
In this study, we used high-throughput RNA sequencing to identify mRNAs, long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) that are differentially expressed in the Substantia Nigra (SN) of aged and young rats. Gene Ontology and Kyoto Encyclopedia of Genes

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