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Principaux documents

SAB4500378

Sigma-Aldrich

Anti-Collagen IV α3 (Cleaved-Pro1426) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

CO4A3, COL4A3, Collagen α-3(IV) chain, Goodpasture antigen, Tumstatin

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 27 kDa

Espèces réactives

human

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:40000
western blot: 1:500-1:1000

Numéro d'accès NCBI

Q01955

Numéro d'accès UniProt

Q01955

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

proteolytically cleaved (Pro1426)

Informations sur le gène

human ... COL4A3(1285)

Description générale

Collagen type IV alpha 3 chain (COL4A3) gene with 52 exons, codes for the α3 chain of type IV collagen. COL4A3 protein is the vital structural protein in the basement membrane. COL4A3 gene is located on human chromosome 2q36.3. Anti-Collagen IV α3 (cleaved-pro1426) antibody detects endogenous levels of fragment of activated collagen IV α3 (cleaved-pro1426) protein.

Immunogène

The antiserum was produced against synthesized peptide derived from human Collagen IV alpha3.

Immunogen Range: 1407-1456

Actions biochimiques/physiologiques

Type IV collagen plays a key role in cell adhesion, proliferation, migration, survival, and differentiation. It maintains the assembly and mechanical stability by acting as a scaffold. Collagen type IV alpha 3 chain (COL4A3) mutations are associated with Alport syndrome (AS). Heterozygous mutations in the COL4A4 gene are observed in individuals with benign familial hematuria (BFH). Alterations in the COL4A3 gene also result in diabetic kidney disease from maturity-onset diabetes.

Caractéristiques et avantages

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Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

C Cervera-Acedo et al.
BMC nephrology, 18(1), 325-325 (2017-11-02)
Alport syndrome is an inherited renal disorder characterized by glomerular basement membrane lesions with hematuria, proteinuria and frequent hearing defects and ocular abnormalities. The disease is associated with mutations in genes encoding α3, α4, or α5 chains of type IV
Laurence Heidet et al.
Journal of the American Society of Nephrology : JASN, 12(1), 97-106 (2001-01-03)
Mutations in either the COL4A3 or the COL4A4 genes, encoding the alpha3 and alpha4 chains of type IV collagen, are responsible for the autosomal-recessive form of Alport syndrome, a progressive hematuric nephropathy characterized by glomerular basement membrane abnormalities. Reported here
Liang Xia et al.
Disease markers, 2019, 8705989-8705989 (2019-03-19)
Mutations in the COL4A3 gene are frequently reported to be associated with various types of hereditary nephropathy. COL4A3 encodes the α3 chain of type IV collagen, which is the main structural protein in the basement membrane. Mutations in this gene
Daniel Öhlund et al.
BMC cancer, 13, 154-154 (2013-03-28)
Pancreatic cancer shows a highly aggressive and infiltrative growth pattern and is characterized by an abundant tumor stroma known to interact with the cancer cells, and to influence tumor growth and drug resistance. Cancer cells actively take part in the

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