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Key Documents

SAB4300255

Sigma-Aldrich

Anti-phospho-NTRK2 (pTyr515) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Anti-GP145-TrkB antibody produced in rabbit, Anti-TRKB antibody produced in rabbit, Anti-neurotrophic tyrosine kinase, receptor, type 2 antibody produced in rabbit

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About This Item

Numéro MDL:
MFCD01092509
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

~140 kDa

Espèces réactives

mouse, rat, human

Concentration

1 mg/mL

Technique(s)

indirect immunofluorescence: 1:100-1:200

Isotype

IgG

Séquence immunogène

(P-Q-Y-PF-G)

Numéro d'accès NCBI

NP_001007098.1

Numéro d'accès UniProt

Q16620

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pTyr515)

Informations sur le gène

human ... NTRK2(4915)

Description générale

NTRK2 (neurotrophic tyrosine kinase receptor type 2) is also known as TRKB (tropomyosin receptor kinase B). It belongs to the Trk family of neurotrophin receptors. It is located on chromosome 9q21.32.

Immunogène

Peptide sequence around phosphorylation site of tyrosine 515 (P-Q-Y(p)-F-G), according to the protein NTRK2.

Application

Anti-phospho-NTRK2 (pTyr515) antibody has been used in western blotting.

Actions biochimiques/physiologiques

In NB (neuroblastoma), NTRK2 (neurotrophic tyrosine kinase receptor type 2) controls the favorable and unfavorable clinical actions. It also controls the roles of glutamate receptor and synaptic plasticity in the amygdala .

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Description de la cible

Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.

Forme physique

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Entrectinib is a potent inhibitor of Trk-driven neuroblastomas in a xenograft mouse model
Iyer R, et al.
Cancer Letters (2016)
A common NTRK2 variant is associated with emotional arousal and brain white-matter integrity in healthy young subjects
Spalek K, et al.
Translational Psychiatry (2016)
Dysregulation of TrkB phosphorylation and proBDNF protein in adenylyl cyclase 1 and 8 knockout mice in a model of fetal alcohol spectrum disorder
Susick LL, et al.
Alcohol (2016)
Case Report: Next generation sequencing identifies a NAB2-STAT6 fusion in Glioblastoma
Diamandis P, et al.
Diagnostic Pathology (2016)
Andrés González-Gutiérrez et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(42), 8042-8054 (2020-09-16)
Brain-derived neurotrophic factor (BDNF) is a key regulator of the morphology and connectivity of central neurons. We have previously shown that BDNF/TrkB signaling regulates the activity and mobility of the GTPases Rab5 and Rab11, which in turn determine the postendocytic
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