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S6324

Sigma-Aldrich

Monoclonal Anti-SNX6 antibody produced in mouse

clone SNX6-76, ascites fluid, buffered aqueous solution

Synonyme(s) :

Anti-MSTP010, Anti-Sorting Nexin 6, Anti-TFAF2, Anti-Tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

ascites fluid

Type de produit anticorps

primary antibodies

Clone

SNX6-76, monoclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~47 kDa

Espèces réactives

mouse, human, bovine, rat

Conditionnement

antibody small pack of 25 μL

Technique(s)

indirect ELISA: suitable
western blot: 1:2,500-1:5,000 using total extracts of A549 cells

Isotype

IgA

Numéro d'accès UniProt

Q9UNH7

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... SNX6(58533)
mouse ... Snx6(72183)
rat ... Snx6(362738)

Catégories apparentées

Description générale

Monoclonal Anti-SNX6 (mouse IgA isotype) is derived from the hybridoma SNX6-76 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice.
SNX6 (sorting nexin 6) is a BACE1 (Β-site APP cleaving enzyme-1)-associated protein and a constituent of retromer. It belongs to the sorting nexin (SNX) family that has a PX (Phox homology) domain at its amino terminus and a BAR (Bin/amphiphysin/Rvc) domain at its carboxyl region. It is located on chromosome 14q13.

Application

Monoclonal Anti-SNX6 antibody produced in mouse has been used in immunoblotting and ELISA.

Actions biochimiques/physiologiques

SNX6 (sorting nexin 6) helps in retrograde trafficking of the cation-independent mannose-6-phosphate receptor (CI-MPR) and sortilin. Interaction of SNX6 with breast cancer metastasis suppressor-1 induces transcriptional repression. It helps in the synthesis of lamin A and its transportation to the nuclear envelope .

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression
Rivera J, et al.
Journal of Cellular Biochemistry, 111(6), 1464-1472 (2010)
Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes
Kamnasaran D, et al.
Genomics, 85(5), 608-621 (2005)
The proximity-labeling technique BioID identifies sorting nexin 6 as a member of the insulin-like growth factor 1 (IGF1)-IGF1 receptor pathway
Bareja A, et al.
Test, 293(17), 6449-6459 (2018)
Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope
Gonzalez-Granado JM, et al.
PLoS ONE, 9(12) (2014)
Akshay Bareja et al.
The Journal of biological chemistry, 293(17), 6449-6459 (2018-03-14)
The insulin-like growth factor 1 receptor (IGF1R) is a receptor tyrosine kinase with critical roles in various biological processes. Recent results from clinical trials targeting IGF1R indicate that IGF1R signaling pathways are more complex than previously thought. Moreover, it has
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