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S5545

Sigma-Aldrich

Anti-Serotonin antibody produced in rabbit

whole antiserum

Synonyme(s) :

Anti-Serotonin, Rabbit Anti-Serotonin, Serotonin Detection Antibody

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About This Item

Numéro MDL:
MFCD00162839
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

whole antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Contient

15 mM sodium azide

Espèces réactives

rat, human

Conditionnement

antibody small pack of 25 μL

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:8,000 using sections of normal human appendix or serotonin-containing carcinoid tumors
immunohistochemistry (frozen sections): 1:5,000 using perfusion-fixed (4% paraformaldehyde), frozen sections of rat brain.

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... HTR1A(3350)

Description générale

Serotonin/5-HT (5-hydroxytryptamine) is a neurotransmitters present in the brain. Anti-Serotonin specifically stains enterochromaffin cells in formalin-fixed, paraffin-embedded sections of normal human appendix and serotonin-containing carcinoid tumors. In the central nervous system (CNS), the antiserum reacts with serotonin-containing fibers in perfusion-fixed, free-floating sections of rat brain.

Spécificité

The antibody reacts with serotonin-containing fibers in paraformaldehyde perfusion-fixed, frozen sections of rat brain. The product specifically stains enterochromaffin cells in formalin-fixed, paraffin embedded sections of normal human appendix and serotonin-containing carcinoid tumors.

Immunogène

Serotonin creatinine sulfate complex conjugated with formaldehyde to BSA.

Application

Anti-Serotonin antibody has been used in immunocytochemistry.

Actions biochimiques/physiologiques

Serotonin/5-HT, the midbrain raphe system controls mood, emotion, cognition and motor functions, circadian and neuroendocrine rhythms, like food intake, sleep and reproductive activity. It participates in natural reward-related physiology and behaviour, from feeding to sexual activity.

Forme physique

Supplied as a liquid containing 15 mM sodium azide as preservative.

Stockage et stabilité

For continuous use, store at 2-8 °C for a maximum of one month. For extended storage freeze in working aliquots. Repeated freezing and thawing, or storage in "frost-free" freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
099M4874V
049M4775V
088M4835V
078M4817V
087M4758V

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

K W Whitaker et al.
Journal of neurophysiology, 106(1), 127-137 (2011-04-01)
Social life affects brain function at all levels, including gene expression, neurochemical balance, and neural circuits. We have previously shown that in the cichlid fish Astatotilapia burtoni brightly colored, socially dominant (DOM) males face a trade-off between reproductive opportunities and
Albert J Poustka et al.
Genome biology, 8(5), R85-R85 (2007-05-18)
The genome of the sea urchin Strongylocentrotus purpuratus has recently been sequenced because it is a major model system for the study of gene regulatory networks. Embryonic expression patterns for most genes are unknown, however. Using large-scale screens on arrays
Central serotonin depletion affects rat brain areas differently: a qualitative and quantitative comparison between different treatment schemes.
Kornum BR, et al.
Neuroscience Letters, 392(1-2), 129-134 (2006)
Roles for serotonin in neuroembryogenesis.
Bernard H, et al.
Serotonin, 477-506 (1981)
A review of central 5-HT receptors and their function
Barnes NM, et al.
Neuropharmacology, 38(8), 1083-1152 (1999)
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