S1442

Sordarin sodium salt

from Sordaria araneosa, ≥98% (HPLC), solid

• Formule empirique (notation de Hill): C₂₇H₃₉NaO₈
• Numéro CAS: 463356-00-5
• Poids moléculaire : 514.58
• Numéro MDL: MFCD08277029
• Code UNSPSC : 51111800
• ID de substance PubChem : 24899480
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: Sordaria araneosa
• Niveau de qualité: 200
• Pureté: ≥98% (HPLC)
• Forme: solid
• Solubilité: H₂O: soluble ≤10 mg/mL
• Spectre d'activité de l'antibiotique: fungi
• Mode d’action: protein synthesis | interferes
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Chaîne SMILES: [Na+].[H]C(=O)[C@]12C[C@]3([H])C=C(C(C)C)[C@@]1(C([O-])=O)[C@]3(CO[C@@H]4O[C@H](C)[C@@H](OC)[C@@H](O)[C@@H]4O)C[C@]5([H])[C@H](C)CC[C@@]25[H]
• InChI: 1S/C27H40O8.Na/c1-13(2)19-8-16-9-25(11-28)18-7-6-14(3)17(18)10-26(16,27(19,25)24(31)32)12-34-23-21(30)20(29)22(33-5)15(4)35-23;/h8,11,13-18,20-23,29-30H,6-7,9-10,12H2,1-5H3,(H,31,32);/q;+1/p-1/t14-,15-,16+,17-,18-,20+,21+,22-,23-,25+,26+,27+;/m1./s1
• Clé InChI: ILUKWKGTAAZHDW-IGICPMPSSA-M

Description

Application

Soradrin sodium salt has been used as an antifungal compound to treat mycelia for immunofluorescence microscopy studies. It may be used in in vitro diphtheria toxin sensitivity assays.

Actions biochimiques/physiologiques

Sordarin is an antifungal metabolite possessing a tetracyclic diterpene glycoside structure. It is a highly potent inhibitor of eukaryotic protein synthesis with selectivity for the fungal translation machinery. The elongation factor EF-2 is the molecular target for sordarin. It blocks ribosomal translocation by stabilizing the EF2-ribosome complex in a manner similar to that of fusidic acid in the bacterial system. Additional cellular components (including rpP0, which is an essential protein of the ribosomal large subunit stalk) are involved in its mechanism of action. Sordarin inhibits in vitro translation in the pathogenic fungi C. albicans, C. glabrata, and C. neoformans. In addition to its therapeutic potential, sordarin is a useful tool for the analysis of protein translation events.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)