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Key Documents

P6905

Sigma-Aldrich

Polythymidylic acid sodium salt

homopolymer

Synonyme(s) :

Poly(dT)

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About This Item

Numéro CAS:
85597-60-0
Numéro MDL:
MFCD00132065
Code UNSPSC :
41106305
Nomenclature NACRES :
NA.51

Source biologique

synthetic (organic)

Niveau de qualité

200

Forme

powder

Température de stockage

−20°C

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Application

Polythymidylicacid sodium salt has been used as a control to compare with poly(A) in aforce-extension experiment to investigate differences in mechanical properties. Polythymidylic acid (Poly(dT)) may be used to study the characteristics of single-stranded DNA binding proteins.

Actions biochimiques/physiologiques

Polythymidylicacid, also known as poly-deoxythymidine (poly-dT), has various applications inmolecular biology research. One of its most common uses is for mRNApurification, where it is utilized to isolate mRNA from a mixture of RNAmolecules for the preparation of cDNA libraries. In addition, poly-dT can beused as a tool for the detection of microbial contamination in water samples.It can also be used for the purification of mRNA-protein fusion molecules inmRNA Display selections.

Définition de l'unité

One unit will yield an A260 of 1.0 in 1.0 ml of water (1 cm light path).

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Poly[d(I-C)] lyophilized, pkg of 10 U (10108812001 [A<sub>260</sub> units]), pkg of 50 U (11219847001 [A<sub>260</sub> units])

Roche

POLYDIC-RO

Poly[d(I-C)]

Alexander G Kozlov et al.
Biochemistry, 49(38), 8266-8275 (2010-08-28)
Deinococcus radiodurans single-stranded (ss) DNA binding protein (DrSSB) originates from a radiation-resistant bacterium and participates in DNA recombination, replication, and repair. Although it functions as a homodimer, it contains four DNA binding domains (OB-folds) and thus is structurally similar to
Byul Nim Oh et al.
Dalton transactions (Cambridge, England : 2003), 40(24), 6494-6499 (2011-05-13)
In this study, an assay to quantify the presence of mercuric ions and methyl mercury by double-stranded DNA containing a poly(dT) sequence was developed using a light switch compound, Ru(phen)(2)(dppz)(2+) (1), which is known to intercalate into double-stranded DNA. Upon
Gregor Witte et al.
Nucleic acids research, 33(5), 1662-1670 (2005-03-23)
The highly conserved bacterial single-stranded DNA-binding (SSB) proteins play an important role in DNA replication, repair and recombination and are essential for the survival of the cell. They are functional as tetramers, in which four OB(oligonucleotide/oligosaccharide binding)-folds act as DNA-binding
Paweł Filipkowski et al.
Extremophiles : life under extreme conditions, 10(6), 607-614 (2006-08-10)
We report the identification and characterization of the single-stranded DNA-binding protein (SSB) from the mesophile and highly radiation-resistant Deinococcus radiopugnans (DrpSSB). PCR-derived DNA fragment containing the complete structural gene for DrpSSB protein was cloned and expressed in Escherichia coli. The
Józef Kur et al.
Acta biochimica Polonica, 52(3), 569-574 (2005-08-06)
Single-stranded DNA-binding proteins (SSBs) play essential roles in DNA replication, recombination, and repair in bacteria, archaea and eukarya. The SSBs share a common core ssDNA-binding domain with a conserved OB (oligonucleotide/oligosaccharide binding) fold. This ssDNA-binding domain was presumably present in

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