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Merck
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Key Documents

P5864

Sigma-Aldrich

Proteoglycan from bovine nasal septum

chromatographically purified

Synonyme(s) :

Bovine Proteoglycan, Nasal Proteoglycan

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About This Item

Numéro MDL:
MFCD00212609
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.61

Source biologique

bovine nasal septum

Niveau de qualité

100

Forme

powder

Technique(s)

cell culture | stem cell: suitable

Numéro d'accès UniProt

F1MDS0

Température de stockage

−20°C

Informations sur le gène

bovine ... PRG4(280867)

Description générale

Proteoglycans are made up of a core protein to which glycosaminoglycan chains are linked covalently. They are present in many organs, and tissues and found abundantly in the vertebrate cartilage matrix. Proteoglycans are located in the extracellular and pericellular matrix of many cells.

Application

Proteoglycan from bovine nasal septum contains 86% chondroitin sulfate and so has been used to study the effects of chondroitin sulfate proteoglycan in vitro. It has been shown to promote survival of neural stem cells in culture.
Proteoglycan from bovine nasal septum has been used in the induction of arthritis in mice.

Actions biochimiques/physiologiques

Proteoglycans are involved in tissue organization and promote cell growth and specialized tissue maturation. They act as biological filters and regulate collagen fibrillogenesis, skin tensile strength, and neurite growth. Proteoglycans are also involved in modulating growth-factor activities, affecting tumor cell growth and invasion, and promoting corneal transparency.

Notes préparatoires

Chromatographically purified using 7M urea on DEAE-cellulose by modified procedure by Antonopoulos.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Muly Tham et al.
PloS one, 5(12), e15341-e15341 (2010-12-24)
Understanding how autocrine/paracrine factors regulate neural stem cell (NSC) survival and growth is fundamental to the utilization of these cells for therapeutic applications and as cellular models for the brain. In vitro, NSCs can be propagated along with neural progenitors
Antonopoulos, C.A.
Biochimica et Biophysica Acta, 338, 108-119 (1974)
M Kopec et al.
Scientific reports, 9(1), 166-166 (2019-01-19)
We have shown that Raman microspectroscopy is a powerful method for visualization of glycocalyx offering cellular interrogation without staining, unprecedented spatial and spectral resolution, and biochemical information. We showed for the first time that Raman imaging can be used to

Articles

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

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