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P4380

Sigma-Aldrich

Protamine sulfate

powder

Synonyme(s) :

Salmine, Salmine from salmon

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About This Item

Numéro CAS:
53597-25-4
Numéro MDL:
MFCD00132091
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77

product name

Protamine sulfate salt from salmon, Grade II

Source biologique

fish (salmon)

Niveau de qualité

200

Type

Grade II

Forme

powder

Couleur

white to off-white

Solubilité

6 M HCl: 25 mg/mL, clear, colorless to light yellow

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Description générale

Protamine sulfate (PS), a polycationic, positively charged protein is mostly made up of poly(l-arginine). It is obtained from salmon sperm protein.

Application

Protamine sulfate salt from salmon has been used in the generation of protamine silica nanocomposites.
May be used for the removal of DNA from protein samples or for the purification of DNA binding proteins. It may be used as an alternative to polybrene in retroviral-mediated gene transfer.

Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.
Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.

Actions biochimiques/physiologiques

Protamine sulfate is highly preferred in cardiovascular surgical procedures to reverse the anticoagulant properties of heparin. It is used for biomedical and biotechnological applications due to its biodegradablity.
Protamine sulfate is a small cationic protein that binds and precipitates DNA. Neutralizes the anticoagulant activity of heparin. Inhibits lipoprotein lipase.

Qualité

May contain insolubles as well as histones.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Drug-induced pulmonary disease
Murray and Nadel's Textbook of Respiratory Medicine, 1275-1294 (2016)
Jacob F Warner et al.
Methods in molecular biology (Clifton, N.J.), 1128, 211-221 (2014-02-26)
The Hedgehog pathway has been shown to be an important developmental signaling pathway in many organisms (Ingham and McMahon. Genes Dev 15:3059-3087, 2001). Recently that work has been extended to developing echinoderm embryos (Walton et al. Dev Biol 331(1):26-37, 2009).
Protamine-templated biomimetic hybrid capsules: efficient and stable carrier for enzyme encapsulation
Zhang Y, et al.
Chemistry of Materials, 20(3), 1041-1048 (2007)
Implications of protein-and Peptide-based nanoparticles as potential vehicles for anticancer drugs
Advances in Protein Chemistry and Structural Biology, 98, 169-221 (2015)
Chitkala Satyanarayana et al.
BMC cancer, 4, 26-26 (2004-06-23)
We determined the effect of andrographolide and one of its novel semi-synthetic analog, DRF 3188, on the cell cycle of MCF 7 breast cancer cells. The effect of the compounds on cell cycle was determined using FACS and western blot
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