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P3657

Sigma-Aldrich

Pyridoxal 5′-phosphate hydrate

powder, BioReagent, suitable for cell culture

Synonyme(s) :

3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde, Codecarboxylase, PLP, Pyridoxal 5-phosphate

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About This Item

Formule empirique (notation de Hill):
C8H10NO6P · xH2O
Numéro CAS:
853645-22-4
Poids moléculaire :
247.14 (anhydrous basis)
Numéro Beilstein :
234749
Numéro CE :
200-208-3
Numéro MDL:
MFCD00006333
Code UNSPSC :
12352205
ID de substance PubChem :
24898438
Nomenclature NACRES :
NA.75

Gamme de produits

BioReagent

Pureté

≥98%

Forme

powder

Poids mol.

Mw 247.14 g/mol

Technique(s)

cell culture | mammalian: suitable

Couleur

off-white to yellow-brown

Pf

140-143 °C

Solubilité

1 M HCl: soluble 50 mg/mL, clear, colorless to light yellow-green

Température de stockage

−20°C

Chaîne SMILES 

CC1=NC=C(COP(O)(O)=O)C(C([H])=O)=C1O

InChI

1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)

Clé InChI

NGVDGCNFYWLIFO-UHFFFAOYSA-N

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Description générale

Pyridoxal-phosphate (PLP, pyridoxal-5′-phosphate, P5P) is a prosthetic group of some enzymes. It is the active form of vitamin B6, which comprises three natural organic compounds, pyridoxal, pyridoxamine and pyridoxine. PLP acts as a coenzyme in all transamination reactions, and in some decarboxylation and deamination reactions of amino acids.

Application


  • Hierarchical Surface Architecture of Hemodialysis Membranes for Eliminating Homocysteine Based on the Multifunctional Role of Pyridoxal 5′-phosphate.: Discusses the development of advanced hemodialysis membranes using pyridoxal 5′-phosphate, highlighting its role in reducing homocysteine levels, which could contribute to improved outcomes for dialysis patients (Jiang P et al., 2020).

Produit comparable

Réf. du produit
Description
Tarif

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Ivone Carvalho et al.
Bioorganic & medicinal chemistry, 18(7), 2412-2427 (2010-03-26)
Trypanosoma cruzi trans-sialidase (TcTS) plays a key role in the recognition and invasion of host cells and in enabling the parasite to escape the human immune response. To explore this potential drug target, we have synthesized a small library of
Jennifer H Richens et al.
Biology open, 4(8), 1052-1061 (2015-07-15)
Centrosomes comprise a pair of centrioles surrounded by a matrix of pericentriolar material (PCM). In vertebrate cells, Pericentrin plays an important part in mitotic PCM assembly, but the Drosophila Pericentrin-like protein (PLP) appears to have a more minor role in
Trina Das et al.
The Journal of general virology, 96(Pt 2), 294-310 (2014-10-30)
Chikungunya virus (CHIKV) has recently affected millions of people in the Indian Ocean, with rare cases of encephalopathy and encephalitis occurring in neonates. In the study described herein, the capacity of mouse brain cells to control infection through innate immune
Bogdan F G Popescu et al.
Neurology, 84(2), 148-158 (2014-12-17)
To assess, in a surgical biopsy cohort of active demyelinating lesions, the diagnostic utility of aquaporin-4 (AQP4) immunohistochemistry in identifying neuromyelitis optica (NMO) or NMO spectrum disorder (NMOSD) and describe pathologic features that should prompt AQP4 immunohistochemical analysis and AQP4-immunoglobulin
Alexandros K Kanellopoulos et al.
Cell, 180(6), 1178-1197 (2020-03-24)
Social impairment is frequently associated with mitochondrial dysfunction and altered neurotransmission. Although mitochondrial function is crucial for brain homeostasis, it remains unknown whether mitochondrial disruption contributes to social behavioral deficits. Here, we show that Drosophila mutants in the homolog of
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Articles

Vitamin B6, Pyridoxal and Pyridoxine in Cell Culture

This page segues to comprehensive insights on how Vitamin B6, Pyridoxal and Pyridoxine affect the performance of serum-free, protein-free cell culture systems used for biomanufacturing heterologous proteins including monoclonal antibodies. The page introduces the in vitro chemistry and biochemistry of pyridoxal, pyridoxine.

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