O5761

Osteocalcin fragment 1-49 Human

≥94% (HPLC), solid

• Formule empirique (notation de Hill): C₂₆₉H₃₈₁N₆₇O₈₂S₂
• Numéro CAS: 136461-80-8
• Poids moléculaire : 5929.43
• Numéro MDL: MFCD03457847
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.32

Propriétés

• Pureté: ≥94% (HPLC)
• Forme: solid
• Numéro d'accès UniProt: P02818
• Température de stockage: −20°C
• Informations sur le gène: human ... BGLAP(632)

Description

Amino Acid Sequence

Tyr-Leu-Tyr-Gln-Trp-Leu-Gly-Ala-Pro-Val-Pro-Tyr-Pro-Asp-Pro-Leu-Gla-Pro-Arg-Arg-Gla-Val-Cys-Gla-Leu-Asn-Pro-Asp-Cys-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val [Disulfide Bridge: 23-29]

Description générale

Bone γ-carboxyglutamate protein (BGLAP) or osteocalcin (OCN) is a non-collagenous bone matrix protein expressed by osteoblasts. It possesses a Gla (γ carboxyglutamate) domain. The gene encoding OCN is localized on human chromosome 1q22.

Calcium-binding protein found in dentin and possibly other mineralized tissues.

Application

Human osteocalcin fragment 1-49 has been used for the identification and characterization of glycation adducts on osteocalcin. It has also been used to study its effects on the differentiation of mouse myoblast cell line C2C12.

Actions biochimiques/physiologiques

Bone γ-carboxyglutamate protein (BGLAP) regulates osteogenic differentiation of mesenchymal stromal cells. It has a role in bone turnover and mineralization. The protein also has a role in energy metabolism. BGLAP may act as a mediator between glucose metabolism and bone tissue.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable