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N4663

Sigma-Aldrich

Anti-Nurr1 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-NOT, Anti-NR4A2, Anti-Nuclear receptor of T cells, Anti-TINUR

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About This Item

Numéro MDL:
MFCD02263849
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

mouse, rat, human

Concentration

~1 mg/mL

Technique(s)

immunohistochemistry: 1:100-1:200
western blot: 1:1,000-1:2,000

Numéro d'accès UniProt

F1D8N6

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... NR4A2(4929)
mouse ... Pls3(18827)
rat ... Nr4a2(54278)

Description générale

Nur-related factor 1 (Nurr1) belongs to nuclear receptor super family. It is a brain-specific transcription factor, confined to central nervous system. Additionally, Nurr1 also modulates gene expression by repressing other transcriptional factors. Nurr1 is expressed in developing and mature dopamine neurons, hippocampus and cerebral cortex. It is crucial for the early development of dopamine neurons in midbrain during development, protection and survival of the neurons. Nurr1 may play a very critical role in the development of Parkinson′s disease and other neurodegenerative diseases and in human atherosclerotic lesions
Anti- Nurr1 recognizes human Nurr1.

Immunogène

synthetic peptide corresponding to an internal sequence of human Nurr1.

Application

Anti-Nurr 1 antibody may be used in immunoblotting at a working dilution of 1:1000 to 1:2000. For immunohistochemistry the recommended dilution is 1:100 to 1:200.

Forme physique

Solution in phosphate buffered saline, containing 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

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Asa Wallen-Mackenzie et al.
Genes & development, 17(24), 3036-3047 (2003-12-19)
The retinoid X receptor (RXR) is essential as a common heterodimerization partner of several nuclear receptors (NRs). However, its function as a bona fide receptor for endogenous ligands has remained poorly understood. Such a role would depend on the existence
S W Law et al.
Molecular endocrinology (Baltimore, Md.), 6(12), 2129-2135 (1992-12-01)
We have identified and cloned a novel member of the nuclear receptor superfamily. The cDNA was isolated from a mouse brain cDNA library and encodes a protein 598 amino acids in length with a predicted mol wt of 66 kilodaltons.
Banafsheh Kadkhodaei et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(50), 15923-15932 (2009-12-18)
Transcription factors involved in the specification and differentiation of neurons often continue to be expressed in the adult brain, but remarkably little is known about their late functions. Nurr1, one such transcription factor, is essential for early differentiation of midbrain
Peter I Bonta et al.
Circulation, 121(18), 2023-2032 (2010-04-28)
Restenosis is the major drawback of percutaneous coronary interventions involving excessive activation and proliferation of vascular smooth muscle cells (SMCs). The nuclear receptor Nurr1 is an early response gene known mainly for its critical role in the development of dopamine
Yinxiu Ding et al.
Molecular medicine reports, 14(3), 1993-1999 (2016-07-20)
Parkinson's disease (PD) is a severe neurodegenerative disorder. Although the detailed underlying molecular mechanism remains to be elucidated, the major pathological feature of PD is the loss of dopaminergic (DA) neurons of the substantia nigra. The use of donor stem

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