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M5883

Sigma-Aldrich

7-Methylguanosine 5′-diphosphate sodium salt

≥92.5%

Synonyme(s) :

7-Methyl-gdp, m7GDP

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About This Item

Formule empirique (notation de Hill):
C11H17N5O11P2 · xNa+
Numéro CAS:
104809-16-7
Poids moléculaire :
457.23 (free acid basis)
Numéro MDL:
MFCD00057869
Code UNSPSC :
41106305
ID de substance PubChem :
329818024
Nomenclature NACRES :
NA.51

Source biologique

synthetic (organic)

Niveau de qualité

200

Pureté

≥92.5%

Forme

powder

Solubilité

water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow

Température de stockage

−20°C

Chaîne SMILES 

[Na+].[Na+].C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]2O)c3nc(N)nc([O-])c13

InChI

1S/C11H17N5O11P2.2Na/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(26-10)2-25-29(23,24)27-28(20,21)22;;/h3-4,6-7,10,17-18H,2H2,1H3,(H5-,12,13,14,19,20,21,22,23,24);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1

Clé InChI

VSMXIKIFPKDZJA-IDIVVRGQSA-L

Description générale

7-Methylguanosine 5′-diphosphate (m7GDP) is derived when the human decapping Dcp2 enzyme cleaves the cap of the deadenylated mRNAs during the 5′–3′ mRNA decay pathway.

Application

7-Methylguanosine 5′-diphosphate sodium salt has been used as a component of the elution buffer for the purification of 5’capped RNA.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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M Długosz et al.
Journal of biochemical and biophysical methods, 51(2), 179-193 (2002-06-14)
A method for extracting kinetic and optical parameters from progress curves for protein-ligand association, obtained by stopped-flow experiments, is described. The method is limited to one-step and two-step association kinetics, but it allows concentration of protein and offset of the
Laurent Volpon et al.
RNA (New York, N.Y.), 23(6), 927-937 (2017-03-23)
The eukaryotic translation initiation factor eIF4E acts in the nuclear export and translation of a subset of mRNAs. Both of these functions contribute to its oncogenic potential. While the biochemical mechanisms that underlie translation are relatively well understood, the molecular
Magdalena Lewdorowicz et al.
RNA (New York, N.Y.), 10(9), 1469-1478 (2004-07-27)
Leishmania and other trypanosomatids are early eukaryotes that possess unusual molecular features, including polycistronic transcription and trans-splicing of pre-mRNAs. The spliced leader RNA (SL RNA) is joined to the 5' end of all mRNAs, thus donating a 5' cap that
Zhibo Zhang et al.
Organic & biomolecular chemistry, 1(19), 3404-3409 (2003-10-31)
The reactions of a 5'-cap model compound P1-(7-methylguanosine) P3-guanosine 5',5'-triphosphate, m7GpppG, were studied in the presence of three different macrocyclic amines (2-4) under neutral conditions. The only products observed in the absence of the macrocycles resulted from the base-catalysed imidazole
Anna Wypijewska et al.
Biochemistry, 51(40), 8003-8013 (2012-09-19)
Decapping scavenger (DcpS) enzymes catalyze the cleavage of a residual cap structure following 3' → 5' mRNA decay. Some previous studies suggested that both m(7)GpppG and m(7)GDP were substrates for DcpS hydrolysis. Herein, we show that mononucleoside diphosphates, m(7)GDP (7-methylguanosine
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