K3750

L-Kynurenine sulfate salt

≥98% (HPLC), suitable for ligand binding assays

• Synonyme(s) : β-Anthraniloyl-L-alanine, L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
• Formule linéaire : C₁₀H₁₂N₂O₃ · H₂SO₄
• Numéro CAS: 16055-80-4
• Poids moléculaire : 306.29
• Numéro MDL: MFCD00039104
• Code UNSPSC : 12352209
• ID de substance PubChem : 24896233
• Nomenclature NACRES : NA.26

Propriétés

• product name: L-Kynurenine sulfate salt, crystalline
• Pureté: ≥98% (HPLC)
• Forme: crystalline
• Technique(s): ligand binding assay: suitable
• Couleur: light yellow
• Température de stockage: −20°C
• Chaîne SMILES: OS(O)(=O)=O.N[C@@H](CC(=O)c1ccccc1N)C(O)=O
• InChI: 1S/C10H12N2O3.H2O4S/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15;1-5(2,3)4/h1-4,8H,5,11-12H2,(H,14,15);(H2,1,2,3,4)/t8-;/m0./s1
• Clé InChI: KAXRWMOLNJZCEW-QRPNPIFTSA-N

Description

Application

L-Kynurenine sulfate salt has been used as a substrate to study the enzyme activity of kynurenine aminotransferase. It has also been used in the synthesis of Kyn adducts of certain amino acids .

Actions biochimiques/physiologiques

L-Kynurenine (L-Kyn) is a precursor of kynurenic acid which is the only recognized endogenous excitatory amino acid receptor antagonist in the central nervous system. L-Kyn is known to be a pigment generating component in animals. In mammals, it modulates the transmission of glutamate neurotransmitter. It is also considered to be a sex-attracting pheromone in vertebrates.

L-Kynurenine is a key intermediate in the breakdown of L-tryptophan and the formation of nicotinamide adenine dinucleotide (NAD+) via the kynurenine pathway. L-kynurenine is involved in a variety of neurological processes and diseases. L-kynurenine is a substrate for kynureninase/kynurenine hydrolase; kynurenine 3-monooxygenase and kynurenine-oxoglutarate transaminase.

Key intermediate in the breakdown pathway of tryptophan.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)