I2532
Monoclonal Anti-Interleukin-7 antibody produced in mouse
clone 7417.111, purified immunoglobulin, lyophilized powder
Synonyme(s) :
Anti-IL-7
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About This Item
Numéro MDL:
Code UNSPSC :
51111800
Source biologique
mouse
Conjugué
unconjugated
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
7417.111, monoclonal
Forme
lyophilized powder
Espèces réactives
human
Technique(s)
capture ELISA: suitable
neutralization: suitable
western blot: 1-2 μg/mL
Isotype
IgG1
Numéro d'accès UniProt
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... IL7(3574)
Description générale
Interleukin-7 (IL-7) is a stromal-cell derived cytokine that is important in the development of adaptive immunity and maintenance of T cells and B cells. IL-7 is produced by bone marrow cells, liver and intestinal epithelia cells, dendritic cells, smooth muscle cells, fibroblasts macrophages and keratinocytes. The effect of IL-7 is mediated by IL-7 receptor α chain and by the subsequent activation of JAK/STAT, PI3K and Src kinases. Important roles of IL-7 include proliferation of lymphoid progenitors, survival and homeostasis of naïve and memory T cells
Monoclonal Anti-Interleukin-7 recognizes recombinant human IL-7 (approximately 17 kDa).
Monoclonal Anti-Interleukin-7 recognizes recombinant human IL-7 (approximately 17 kDa).
Spécificité
The antibody has the ability to neutralize the biological activity of recombinant human IL-7. It may also be used as a capture antibody in a human IL-7 ELISA.
Immunogène
purified recombinant human IL-7, expressed in E. coli.
Application
Anti-Interleukin-7 antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. For ELISA the working concentration recommended is 1-2 μg/ml. The antibody is also suitable for neutralization assays.
Forme physique
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Modulating T cell Homeostasis with IL-7: Preclinical and Clinical Studies
Capitini CM et al
J. Int. Med., 266, 141-153 (2009)
Charles D Surh et al.
Immunological reviews, 211, 154-163 (2006-07-11)
The pool of memory T cells is regulated by homeostatic mechanisms to persist for prolonged periods at a relatively steady overall size. Recent work has shown that two members of the common gamma chain (gammac) family of cytokines, interleukin-7 (IL-7)
Shoshana D Katzman et al.
Cytokine, 56(1), 116-121 (2011-08-03)
Regulation of the magnitude and quality of immune responses is dependent on the integration of multiple signals which typically operate through positive and negative feedback loops. Cytokines that promote or limit T cell expansion and differentiation are often both present
K S Schluns et al.
Nature immunology, 1(5), 426-432 (2001-03-23)
The naïve and memory T lymphocyte pools are maintained through poorly understood homeostatic mechanisms that may include signaling via cytokine receptors. We show that interleukin-7 (IL-7) plays multiple roles in regulating homeostasis of CD8+ T cells. We found that IL-7
J T Tan et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(15), 8732-8737 (2001-07-12)
In T cell-deficient conditions, naive T cells undergo spontaneous "homeostatic" proliferation in response to contact with self-MHC/peptide ligands. With the aid of an in vitro system, we show here that homeostatic proliferation is also cytokine-dependent. The cytokines IL-4, IL-7, and
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