I1286

Icariin

≥94% (HPLC)

• Synonyme(s) : 4′-O-methyl-8-γ,γ-dimethylallylkaempferol-3-rhamnoside-7-glucoside
• Formule empirique (notation de Hill): C₃₃H₄₀O₁₅
• Numéro CAS: 489-32-7
• Poids moléculaire : 676.66
• Numéro MDL: MFCD00210516
• Code UNSPSC : 12352205
• ID de substance PubChem : 329815347
• Nomenclature NACRES : NA.25

Propriétés

• Pureté: ≥94% (HPLC)
• Couleur: light yellow to yellow
• Solubilité: DMSO: 50 mg/mL, clear, colorless to dark yellow
• Application(s): metabolomics; vitamins, nutraceuticals, and natural products
• Température de stockage: room temp
• Chaîne SMILES: COc1ccc(cc1)C2=C(O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)C(=O)c4c(O)cc(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)c(C\C=C(\C)C)c4O2
• InChI: 1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1
• Clé InChI: TZJALUIVHRYQQB-XLRXWWTNSA-N

Description

Description générale

Icariin is a prenylated flavonol and the major bioactive compound found in Epimedium herb.

Application

Icariin has been used:

• in the preparation of topical treatment to determine its effects on the improvement of cutaneous wound healing in rats
• to test its analgesic effects on lower back pain (LBP) in rats
• as a potential treatment in osteoporosis condition in rats
• to study its effects on palmitate (PA)-induced insulin resistance in skeletal muscle C2C12 myotubes
• as a neuroprotective agent to study its effects on amyloid-β (Aβ)-induced neuronal insulin resistance in human neuroblastoma SK-N-MC cells

Actions biochimiques/physiologiques

Icariin is a potent neuroprotective agent in neurodegenerative disorders and other disorders affecting the nervous system. It elicits anti-aging properties in unfertilized oocytes against age-related damage. Icariin exerts anti-inflammatory and antifibrotic properties aiding protection in chronic kidney disease (CKD)-associated renal fibrosis in mouse model. It also serves as an excellent antidiabetic and anti-atherosclerotic agent. Icariin is an excellent anti-cancer agent.

Flavonoid glucoside derived from the the Epimedium plant genus. This pharmacologically active constituent or its derivatives have been shown to enhance bone formation, modulate multidrug resistance, enhance neuronal viability, stimulate angiogenesis, and exhibit antioxidant activity.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable