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H0540

Anti-Hepatocyte Growth Factor antibody produced in goat

Name: Anti-Hepatocyte Growth Factor antibody produced in goat
Brand: SIGMA

affinity isolated antibody, lyophilized powder

Synonyme(s) :

Anti-HGF

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About This Item

Numéro MDL:

MFCD00212968

Code UNSPSC :

51111800

Nomenclature NACRES :

NA.41

Source biologique

goat

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

lyophilized powder

Espèces réactives

mouse

Technique(s)

capture ELISA: 0.2-0.8 μg/mL
immunohistochemistry: 5-15 μg/mL
western blot: 0.1-0.2 μg/mL

Numéro d'accès UniProt

Q08048

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

mouse ... Hgf(15234)

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Immunogène

purified, NSO cell-derived recombinant mouse hepatocyte growth factor.

Actions biochimiques/physiologiques

Hepatocyte Growth Factor (HGF) is a multifunctional, heparin-binding factor that stimulates the proliferation of liver cells. The cellular effects of HGF are mediated by its receptor, c-Met, that leads to significant activation of ERK, Src/FAK, STAT3 and PI3K signaling. Various functions of the HGF/c-Met signaling include proliferation, cell survival, motility and adhesion and tissue regeneration. Apart from liver, HGF also mediates regeneration of kidney, lung and gastro-intestines.

Forme physique

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Produit(s) apparenté(s)

Réf. du produit

Description

Tarif

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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HGF as a renotrophic and anti-fibrotic regulator in chronic renal disease.

Shinya Mizuno et al.

Frontiers in bioscience : a journal and virtual library, 13, 7072-7086 (2008-05-30)

Hepatocyte growth factor (HGF) and Met/HGF receptor play roles in dynamic growth and morphogenesis during development and regeneration of organs, including the kidney. In the kidney, HGF targets different types of cells, while its biological actions depend on a target

The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis.

Weon-Kyoo You et al.

BMB reports, 41(12), 833-839 (2009-01-07)

Angiogenesis in tumors is driven by multiple growth factors that activate receptor tyrosine kinases. An important driving force of angiogenesis in solid tumors is signaling through vascular endothelial growth factor (VEGF) and its receptors (VEGFRs). Angiogenesis inhibitors that target this

Hepatocyte growth factor: molecular structure, roles in liver regeneration, and other biological functions.

K Matsumoto et al.

Critical reviews in oncogenesis, 3(1-2), 27-54 (1992-01-01)

Hepatocyte growth factor (HGF) is the most potent mitogen for mature hepatocytes and seems to act as a hepatotropic factor that has not been purified over the past 30 years. HGF was first purified from rat platelets in 1986. HGF

The discovery of hepatocyte growth factor (HGF) and its significance for cell biology, life sciences and clinical medicine.

Toshikazu Nakamura et al.

Proceedings of the Japan Academy. Series B, Physical and biological sciences, 86(6), 588-610 (2010-06-17)

It has been more than 25 years since HGF was discovered as a mitogen of hepatocytes. HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its receptor

The loss of local HGF, an endogenous gastrotrophic factor, leads to mucosal injuries in the stomach of mice.

Rie Nakahira et al.

Biochemical and biophysical research communications, 341(4), 897-903 (2006-02-16)

The stomach is constantly exposed to mechanical and chemical stresses. Under persistent damages, epithelial cell proliferation is required to maintain mucosal integrity. Nevertheless, which ligand system(s) is physiologically involved in gastric defense remains unclear. Herein, we provide evidence that HGF

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