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G8044

Sigma-Aldrich

Anti-phospho-GATA4 (pSer105) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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About This Item

Numéro MDL:
MFCD06798487
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 46 kDa

Espèces réactives

mouse

Conditionnement

pkg of (1 vl = 100ul)

Technique(s)

western blot: 1:500

Numéro d'accès UniProt

Q08369

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... GATA4(2626)
mouse ... Gata4(14463)
rat ... Gata4(54254)

Immunogène

Anti-phospho-GATA4 (pSer105) antibody produced in rabbit is suitable for western blotting at working dilution 1:500.
synthetic phosphopeptide derived from the region of GATA-4 that contains serine 105.

Actions biochimiques/physiologiques

GATA-4 has a molar mass of 46kDa and belongs to the GATA family of zinc finger-containing transcription factors. It is involved in the development of cardiac hypertrophy and remodeling. It plays a crucial role in regulating basal and agonist or stress-induced gene expression in cardiac and smooth muscle cell types. Upon agonist stimulation via MEK1-ERK1/2, and weakly via JNK or p38 MAPKs, Ser105 of GATA-4 is phosphorylated. Phosphorylation of GATA-4 by hepatocyte growth factor facilitates cell survival in cardiac muscle cells via MEK/ERK-dependent signaling pathway.

Forme physique

Solution in Dulbecco′s PBS, pH 7.3 with 1 mg/mL BSA and 0.05% Sodium Azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

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Consulter la Bibliothèque de documents

Kazumi Kitta et al.
The Journal of biological chemistry, 278(7), 4705-4712 (2002-12-07)
Hepatocyte growth factor (HGF) is released in response to myocardial infarction and may play a role in regulating cardiac remodeling. Recently, HGF was found to inhibit the apoptosis of cardiac muscle cells. Because GATA-4 can induce cell survival, the effects
Q Liang et al.
Molecular and cellular biology, 21(21), 7460-7469 (2001-10-05)
The zinc finger-containing transcription factor GATA4 has been implicated as a critical regulator of multiple cardiac-expressed genes as well as a regulator of inducible gene expression in response to hypertrophic stimulation. Here we demonstrate that GATA4 is itself regulated by

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