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G8035

Sigma-Aldrich

Anti-Glial Cell-derived Neurotrophic Factor (GDNF) antibody produced in goat

IgG fraction of antiserum, lyophilized powder

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About This Item

Numéro MDL:
MFCD00676456
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.41

Source biologique

goat

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

lyophilized powder

Espèces réactives

human

Technique(s)

neutralization: suitable

Numéro d'accès UniProt

P39905

Température de stockage

−20°C

Informations sur le gène

human ... GDNF(2668)

Description générale

The antibody neutralizes the biological activity of recombinant human GDNF.

Immunogène

recombinant human GDNF expressed in Escherichia coli.

Actions biochimiques/physiologiques

Glial cell-derived neurotrophic factor is a potent neurotrophic factor that is important for the maintenance, regeneration and survival of specific neuronal cells including autonomic neurons, motoneurons, noradrenergic and seotonergic neurons. Additionally, it promotes the invasion and metastatic behavior of certain types of cancers by activating ERK, p38, JNK and AP-1 mediated cell signaling.

Forme physique

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline

Notes préparatoires

Purified using protein G.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Jing-Yuan Chuang et al.
Oral oncology, 49(12), 1103-1112 (2013-09-28)
Perineural invasion is a prominent clinical feature of various cancers, which causes difficulty in curative resection. Glial cell-derived neurotrophic factor (GDNF), a potent neurotrophic factor, plays an important role in the invasive and metastatic behavior of various cancers. The aim
Mikko Airavaara et al.
Parkinsonism & related disorders, 18 Suppl 1, S143-S146 (2011-12-23)
Although initially thought to be important primarily in neural development, a number of trophic proteins have been found to have neuroprotective and neuroregenerative activity in the adult central nervous system, particularly for midbrain dopamine neurons (MDN). Neurorestoration is potentially feasible
Shelley J Allen et al.
Pharmacology & therapeutics, 138(2), 155-175 (2013-01-26)
Glial cell-derived neurotrophic factor (GDNF), and the neurotrophin nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are important for the survival, maintenance and regeneration of specific neuronal populations in the adult brain. Depletion of these neurotrophic factors has been
Yukihisa Yoshino et al.
Brain research, 1422, 1-12 (2011-10-11)
Stimulation of rat microglia with lipopolysaccharide (LPS) in vitro induces production of the inflammatory/cytotoxic cytokine tumor necrosis factor alpha (TNFα) along with superoxide anion (O(2)(-)) and nitric oxide (NO). In this study, we investigated the role of O(2)(-) and NO

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