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Key Documents

G3643

Sigma-Aldrich

α1-Acid Glycoprotein from bovine plasma

≥99%

Synonyme(s) :

Orosomucoid

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About This Item

Numéro CAS:
66455-27-4
Numéro MDL:
MFCD00131224
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.61

Source biologique

bovine plasma

Niveau de qualité

200

Pureté

≥99%

Forme

powder

Technique(s)

electrophoresis: suitable
mass spectrometry (MS): suitable

Numéro d'accès UniProt

Q3SZR3

Température de stockage

2-8°C

Informations sur le gène

bovine ... ORM1(497200)

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Description générale

α1-Acid Glycoprotein (AGP, orosomucoid) from bovine plasma belongs to ‘lipocalins′ family which binds and transports small hydrophobic molecules. AGP is further classified into the subfamily ‘immunocalins′ which immunomodulates the inflammatory reactions. AGP is primarily produced in the liver, in few extra hepatic tissues and is present in neutrophil granules. Healthy cattle possesses 0.3 mg of AGP/ ml of concentrated serum.
α1-Acid glycoprotein (AGP, orosomucoid) is the major plasma glycoprotein with a molecular weight of 41-43 kDa. It is responsible for possessing the complex type of glycans.

Application

α1-Acid Glycoprotein (AGP) from bovine plasma has been used:
  • in mass spectrometry analysis to confirm the presence of Neu5Ac and Neu5Gc distribution in human and bovine AGP respectively
  • for pretreating the microvessel before perfusing the MDA-MB-231 cells for tumor adhesion studies
  • in the composition of tear model
  • as a reference in sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE)

α1-Acid glycoprotein was used to study nonviral gene delivery to the lung with copolymer-protected and transferrin-modified polyethylenimine

Actions biochimiques/physiologiques

α1-Acid Glycoprotein from bovine plasma is an acute phase protein. It has anti-inflammatory potential and its concentration increases several folds during injury. AGP increases the chemotactic activity and life span of monocytes and inhibits neutrophil degranulation. Serum AGP levels differentiates sepsis from systemic inflammatory response syndrome (SIRS).

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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alpha1-Acid glycoprotein modulates phagocytosis and killing of Escherichia coli by bovine polymorphonuclear leucocytes and monocytes
Lecchi C, et al.
The Veterinary Journal, 196(1), 47-51 (2013)
Identification of the bovine alpha1-acid glycoprotein in colostrum and milk
Ceciliani F, et al.
Veterninary Research, 36(5-6), 735-746 (2005)
alpha-1-Acid glycoprotein as a biomarker for the early diagnosis and monitoring the prognosis of sepsis
Xiao K, et al.
Journal of Critical Care, 30(4), 744-751 (2015)
Adhesion of malignant mammary tumor cells MDA-MB-231 to microvessel wall increases microvascular permeability via degradation of endothelial surface glycocalyx
Cai B, et al.
Journal of Applied Physiology, 113(7), 1141-1153 (2012)
Mohamed F AlAjmi et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 225, 117457-117457 (2019-08-27)
Drug-binding and interactions with plasma proteins strongly affect their efficiency of delivery, hence considered as a key factor in determining the overall pharmacological action. Alpha-1-acid glycoprotein (AGP), a second most abundant plasma protein in blood circulation, has unique drug binding
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A Rapid, Streamlined Workflow for Glycan Sample Preparation and Analysis by LC-MS

The use of PNGase Fast denaturing buffer and enzyme yielded results similar to a conventional 20-hour protocol with overnight digest while reducing workflow time to about 1 hour with a 15-minute digest.

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

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