F6557
FYN A, active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonyme(s) :
MGC45350, SLK, SYN
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About This Item
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32
Produits recommandés
Produit recombinant
expressed in baculovirus infected Sf9 cells
Niveau de qualité
Gamme de produits
PRECISIO® Kinase
Pureté
≥70% (SDS-PAGE)
Forme
buffered aqueous glycerol solution
Activité spécifique
141-195 nmol/min·mg
Poids mol.
~85 kDa
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−70°C
Informations sur le gène
human ... FYN(2534)
Description générale
FYN proto-oncogene is a member of the Src family of tyrosine kinases, and has a molecular weight of 59kDa. Post-synthesis this protein is N-myristoylated on cytoplasmic polysomes. It is palmitoylated after it has been targeted to the cell membrane. This protein can also be acylated twice, which leads to its clustering into microdomains in the caveolae-like membrane.
Actions biochimiques/physiologiques
FYN proto-oncogene interacts with multiple signaling molecules, and is involved in T-cell receptor (TCR) signaling, brain function control, along with the control of adhesion-mediated signaling. It might have potential as a target for autoimmune disorders and alcohol addiction. It is also implicated in melanoma tumorigenes in a immunoglobulin (Ig)E-mediated manner. In mesenchymal stem cells, it controls RhoA and adipogenesis, through its interaction with mTORC2 (mammalian target of rapamycin complex 2).
Forme physique
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Informations légales
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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William R Thompson et al.
Stem cells (Dayton, Ohio), 31(11), 2528-2537 (2013-07-10)
Mechanical strain provides an anti-adipogenic, pro-osteogenic stimulus to mesenchymal stem cells (MSC) through generating intracellular signals and via cytoskeletal restructuring. Recently, mTORC2 has been shown to be a novel mechanical target critical for the anti-adipogenic signal leading to preservation of
Guillermina Yanek Jiménez-Andrade et al.
Journal of hematology & oncology, 6, 56-56 (2013-08-07)
High concentrations of plasmatic IgE have been related to distinct systemic inflammatory conditions that frequently predispose individuals to hypersensitivity reactions. Although effects of IgE have been suggested to relay on the low-intensity activation of distinct effector elements of the immune
Kechen Ban et al.
Blood, 111(5), 2904-2908 (2008-01-09)
Chronic myelogenous leukemia (CML) invariably progresses to blast crisis, which represents the most proliferative phase of the disease. The BCR-ABL1 oncogene stimulates growth and survival pathways by phosphorylating numerous substrates, including various Src family members. Here we describe up-regulation, in
M D Resh
The international journal of biochemistry & cell biology, 30(11), 1159-1162 (1998-12-05)
Fyn is a 59 kDa member of the Src family of tyrosine kinases. The protein is synthesized and N-myristoylated on cytosolic polysomes and then rapidly targeted to the plasma membrane, where it is palmitoylated. Dually acylated Fyn clusters in caveolae-like
Hyang-Sook Hoe et al.
The Journal of biological chemistry, 283(10), 6288-6299 (2007-12-20)
Dab1 is an intracellular adaptor protein that interacts with amyloid precursor protein (APP) and apoE receptor 2 (apoEr2), increases their levels on the cell surface, and increases their cleavage by alpha-secretases. To investigate the mechanism underlying these alterations in processing
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