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Key Documents

E2250

Sigma-Aldrich

Ellagic acid

≥95% (HPLC), powder, from tree bark

Synonyme(s) :

4,4′,5,5′,6,6′-Hexahydroxydiphenic acid 2,6,2′,6′-dilactone, Alizarin Yellow, Benzoaric acid, Elagostasine, Eleagic acid, Gallogen, Lagistase

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About This Item

Formule empirique (notation de Hill):
C14H6O8
Numéro CAS:
Poids moléculaire :
302.19
Numéro Beilstein :
47549
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352205
ID de substance PubChem :
Nomenclature NACRES :
NA.77

Source biologique

tree bark

Niveau de qualité

Pureté

≥95% (HPLC)

Forme

powder

Durée de conservation

5 yr

Solubilité

1 M NaOH: 10 mg/mL

Application(s)

metabolomics
vitamins, nutraceuticals, and natural products

Chaîne SMILES 

Oc1cc2C(=O)Oc3c(O)c(O)cc4C(=O)Oc(c1O)c2-c34

InChI

1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H

Clé InChI

AFSDNFLWKVMVRB-UHFFFAOYSA-N

Informations sur le gène

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Description générale

Ellagic acid is a naturally occurring phenolic acid in many fruits and vegetables, as a secondary plant metabolite. It is commonly found in green tea, pomegranate, strawberries, blackberries, raspberries, and walnuts.

Application

Ellagic acid has been used:
  • to study the metabolism of dietary phenolic acids by Lactobacillus plantarum CECT 748T
  • as a potential substrate for the high production of Lactobacillus plantarum tannase
  • as a standard in the study to examine the phenolic components and anti-oxidant activity of nettle
  • to study the links between dietary ellagic acid and epigenetic modulation of adipogenesis

Actions biochimiques/physiologiques

Ellagic acid has been found to exhibit antioxidant activity by virtue of having an inhibitory effect on the oxidation of low-density lipoproteins. This makes them have a cardioprotective effect on humans. In addition, it shows anticarcinogenic, antifibrotic, antiplasmodial, apoptotic, and chemopreventive activities as well.
Commonly occurring plant polyphenol, inhibitor of glutathione S-transferase. Used for the assay of factor XIIa in plasma. Contact activation in blood coagulation.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves


Certificats d'analyse (COA)

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Les clients ont également consulté

H Hayatsu et al.
Mutation research, 202(2), 429-446 (1988-12-01)
Dietary inhibitors of mutagenesis and carcinogenesis are of particular interest because they may be useful for human cancer prevention. Several mutagenesis inhibitors have been demonstrated to be carcinogenesis inhibitors also, e.g., ellagic acid, palmitoleic acid, and N-acetylcysteine. This means that
Detecting oral kallikrein-targeting therapy through triggered contact activation: A phase I study.
Zonne L M Hofman et al.
The Journal of allergy and clinical immunology, 146(6), 1446-1449 (2020-05-04)
Inhae Kang et al.
The Journal of nutritional biochemistry, 25(9), 946-953 (2014-06-16)
Chromatin remodeling is a key mechanism in adipocyte differentiation. However, it is unknown whether dietary polyphenols are epigenetic effectors for adiposity control. Ellagic acid (EA) is a naturally occurring polyphenol in numerous fruits and vegetables. Recently, EA-containing foods have been
Giorgio Cozza et al.
Journal of medicinal chemistry, 49(8), 2363-2366 (2006-04-14)
Casein kinase 2 (CK2) is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive activity is suspected to underlie its pathogenic potential in neoplasia and other diseases. Using a virtual screening approach, we have identified the ellagic
J Z Altamimi et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 71(6) (2021-04-27)
This study investigated the protective effect of ellagic acid (EA) against diabetic cardiomyopathy (DC) in streptozotocin (STZ)-treated rats and examined if the mechanism of protection involves modulating silent information regulator 1 (SIRT1). Adult male rats were divided into 5 groups

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