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C8352

Anti-CXCR4 (Fusin) (182-196) antibody produced in rabbit

Name: Anti-CXCR4 (Fusin) (182-196) antibody produced in rabbit
Brand: SIGMA

IgG fraction of antiserum, buffered aqueous solution

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About This Item

Numéro MDL:

MFCD01092337

Code UNSPSC :

12352203

Nomenclature NACRES :

NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

human

Technique(s)

western blot: 0.5-1 μg/mL using human HeLa cell extract

Numéro d'accès UniProt

P61073

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CXCR4(7852)

Catégories apparentées

Primary Antibodies

Description générale

Chemokine receptor CXCR-4 also refers as fusin or LESTR is a protein that belongs to G-protein coupled receptor 1 family. It is an essential cofactor for T cell-tropic HIV viruses into CD4+ cells. N-Terminal domain and second extracellular loop of the protein act as a HIV binding sites. Anti-CXCR4 (Fusin) (182-196) antibody can be used to block HIV-1 and HIV-2 fusion and infection of human target cells. Rabbit anti-CXCR4 (Fusin) (182-196) antibody reacts specifically with human CXCR4.

Immunogène

synthetic peptide corresponding to amino acids 182-196 of the second extracellular loop of human CXCR4.

Application

Anti-CXCR4 (Fusin) (182-196) antibody may be used in immunoblotting at a working antibody concentration of 0.5 - 1 μg/ml using human HeLa cell extract. It can also be used in immunohistochemistry.

Autres remarques

The antigen (receptor) is also termed fusin, LESTER and HUMSTR.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Clampdown of inflammation in aging and anticancer therapies by limiting upregulation and activation of GPCR, CXCR4.

Raji R Nair et al.

NPJ aging and mechanisms of disease, 4, 9-9 (2018-09-06)

One of the major pathological outcomes of DNA damage during aging or anticancer therapy is enhanced inflammation. However, the underlying signaling mechanism that drives this is not well understood. Here, we show that in response to DNA damage, ubiquitously expressed

Inhibition of metastasis in a castration resistant prostate cancer model by the quinoline-3-carboxamide tasquinimod (ABR-215050).

Karin Jennbacken et al.

The Prostate, 72(8), 913-924 (2012-01-31)

Tasquinimod (ABR-215050) is an orally active quinoline-3-carboxamide analog that has completed phase II clinical trial in patients with castration resistant prostate cancer, showing promising inhibiting effects on the occurrence of metastasis and delayed disease progression. Its mechanism of action is

Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains.

Z Lu et al.

Proceedings of the National Academy of Sciences of the United States of America, 94(12), 6426-6431 (1997-06-10)

The chemokine receptor CXCR4 functions as a fusion coreceptor for T cell tropic and dual-tropic HIV-1 strains. To identify regions of CXCR4 that are important for coreceptor function, CXCR4-CXCR2 receptor chimeras were tested for the ability to support HIV-1 envelope

A functional heteromeric MIF receptor formed by CD74 and CXCR4.

Verena Schwartz et al.

FEBS letters, 583(17), 2749-2757 (2009-08-12)

MIF is a chemokine-like inflammatory mediator that triggers leukocyte recruitment by binding to CXCR2 and CXCR4. MIF also interacts with CD74/invariant chain, a single-pass membrane-receptor. We identified complexes between CD74 and CXCR2 with a role in leukocyte recruitment. It is

A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains.

J F Berson et al.

Journal of virology, 70(9), 6288-6295 (1996-09-01)

Entry of human immunodeficiency virus type 1 (HIV-1) into cells requires binding to CD4 and fusion with a cellular membrane. Fusion does not occur in most nonhuman cells even when they express human CD4, indicating that one or more human

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