C8198
Anti-Calcitonin Gene Related Peptide antibody produced in rabbit
whole antiserum
Synonyme(s) :
CGRP Antibody - Anti-Calcitonin Gene Related Peptide antibody produced in rabbit, Cgrp Antibody, Anti-CGRP
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About This Item
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
whole antiserum
Type de produit anticorps
primary antibodies
Clone
polyclonal
Contient
15 mM sodium azide
Espèces réactives
rat
Conditionnement
antibody small pack of 25 μL
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
rat ... Calca(24241)
Description générale
Calcitonin Gene Related Peptide (CGRP), a cyclic peptide, belongs to a small family of peptides encoded by the calcitonin/CGRP gene complex. The calcitonin/CGRP gene complex consists of at least two genes, encoding for two forms of CGRP: -CGRP (CGRP-I) and -CGRP (CGRP-II). CGRP is synthesized and co-localized with calcitonin in the parafollicular C-cells of the thyroid gland and medullary thyroid carcinoma. It is principally considered a neuropeptide widely distributed in the central and peripheral nervous systems.
Spécificité
Anti-Calcitonin Gene Related Peptide reacts with CGRP (rat). Cross-reactivity is observed with CGRP (human) and β-CGRP (human).
Immunogène
CGRP-KLH
Application
Anti-Calcitonin Gene Related Peptide antibody produced in rabbit has been used in:
- dot blot immunoassay
- fluorescent labeling
- confocal microscopy
- immunohistofluorescence
- epifluorescence imaging
Anti-Calcitonin Gene Related Peptide antibody produced in rabbit was used for immunohistochemistry of trigeminal ganglia cell cultures at a dilution of 1:200 and for immunocytochemistry of mouse lung slices at a dilution of 1:500.
Actions biochimiques/physiologiques
CGRP is thought to act as a neurotransmitter or neuromodulator, particularly in the regulation of autonomic (e.g., cardiovascular, respiratory, gastrointestinal, taste, food intake and sleep) and limbic functions. CGRP is probably involved with substance P in mediating neurogenic inflammation and transmission of pain stimuli via the peripheral nervous system.
Calcitonin Gene Related Peptide is a G protein-coupled receptor that binds receptor-activity-modifying proteins (RAMP)1, -2 and -3. CLR has been implicated in conditions such as obesity, diabetes, osteoporosis, migraine and cardiovascular disease.
Quantité
delipidized
Forme physique
Supplied as a liquid containing 0.1% sodium azide as a preservative
Stockage et stabilité
For continuous use, store 2-8°C. For extended storage, solution may be frozen in working aliquots. Repeated freezing and thawing, or storage in "frost-free"freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Réf. du produit
Description
Tarif
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Les clients ont également consulté
Juan M Jimenez-Andrade et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(44), 14649-14656 (2010-11-05)
Pain frequently accompanies cancer. What remains unclear is why this pain frequently becomes more severe and difficult to control with disease progression. Here we test the hypothesis that with disease progression, sensory nerve fibers that innervate the tumor-bearing tissue undergo
Lina Almarestani et al.
Molecular pain, 4, 56-56 (2008-11-19)
Pain is a major symptom associated with chronic inflammation. In previous work from our laboratory, we have shown that in animal models of neuropathic pain there is a sprouting of sympathetic fibers into the upper dermis, a territory normally devoid
Kumiko Ishida et al.
Anesthesiology, 121(5), 1068-1079 (2014-07-06)
The aim of this study was to clarify the roles of calcitonin gene-related peptide (CGRP) in postoperative pain and inflammatory pain. αCGRP knockout mice that the authors have developed and wild-type mice were used. Pain behaviors were assessed after incision
Eric L Moore et al.
British journal of pharmacology, 166(1), 66-78 (2011-08-30)
The clinical effectiveness of antagonizing the calcitonin gene-related peptide (CGRP) receptor for relief of migraine pain has been clearly demonstrated, but the road to the development of these small molecule antagonists has been daunting. The key hurdle that needed to
Shin-E Lin et al.
Physiological reports, 3(12) (2015-12-25)
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is expressed in the epithelium of various primate tissues, including lung airway and alveoli. In human lung, CEACAM6 is developmentally and hormonally regulated, protects surfactant function, has anti-apoptotic activity and is dysregulated in
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